药品详细
Pirenzepine(哌仑西平)
化学结构式图
中文名
哌仑西平
英文名
Pirenzepine
分子式
C19H21N5O2
化学名
2-[2-(4-methylpiperazin-1-yl)acetyl]-2,4,9-triazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10-one
分子量
Average: 351.4023
Monoisotopic: 351.169524941
Monoisotopic: 351.169524941
CAS号
28797-61-7
ATC分类
A02B 未知
药物类型
small molecule
阶段
approved
商品名
Bisvanil;Gasteril;Gastrozepin;Leblon;Pirenzepin;Pirenzepina [INN-Spanish];Pirenzepine Gastrozepin;Pirenzepinum [INN-Latin];Tabe;Ulcosan;
同义名
基本介绍
An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as cimetidine and ranitidine. It is generally well tolerated by patients. [PubChem]
生产厂家
封装厂家
参考
Synthesis Reference | Not Available |
General Reference |
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剂型
规格
化合物类型
Type | small molecule |
Classes |
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Substructures |
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适应症
gastric acid RELATED DISORDERS 中和胃酸;
药理
Indication | For the treatment of peptic ulcer, gastric ulcer, and duodenal ulcer. | ||||||
Pharmacodynamics | Pirenzepine belongs to a group of medications called antispasmodics/anticholinergics. These medications are used to relieve cramps or spasms of the stomach, intestines, and bladder. Pirenzepine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness. | ||||||
Mechanism of action | Pirenzepine is a muscarinic receptor antagonist and binds to the muscarinic acetylcholine receptor. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. | ||||||
Absorption | Not Available | ||||||
Volume of distribution | Not Available | ||||||
Protein binding | Not Available | ||||||
Metabolism |
Not Available
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Route of elimination | Not Available | ||||||
Half life | Not Available | ||||||
Clearance | Not Available | ||||||
Toxicity | Not Available | ||||||
Affected organisms |
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Pathways |
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理化性质
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State | solid | ||||||||||||||||||||||||||||||||||||||||||
Experimental Properties |
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Predicted Properties |
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药物相互作用
食物相互作用
- Take 30 minutes before breakfast and at bedtime.