Alquen;Alter-H2;Alvidina;Apo-Ranitidin;Artomil;Azuranit;Coralen;Digestosan;Ergan;Esofex;Fendibina;Gastrial;Gastridina;Gastrolav;Gastrosedol;Kuracid;Label;Lake;Logat;Melfax;Microtid;Mideran;Neugal;Noctone;Noktome;Normon;Novo-Radinine;Nu-Ranit;Pep-Rani;Ptinolin;Quadrin;Quantor;Radin;RAN;Ran H2;Ran Lich;Rani 2;Rani AbZ;Rani-BASF;Rani-nerton;Rani-Puren;Rani-Q;Rani-Sanorania;Raniben;Raniberl;Raniberta;Ranibloc;Ranic;Ranicux;Ranidil;Ranidin;Ranidine;Ranidura;Ranifur;Ranigasan;Ranigast;Ranigen;Ranilonga;Ranimerck;Raniogas;Raniplex;Ranisan;Ranitab;Ranitic;Ranitidin;Ranitidin 1A Pharma;Ranitidin AL;Ranitidin Arcana;Ranitidin Atid;Ranitidin AWD;Ranitidin Basics;Ranitidin Duncan;Ranitidin Dyna;Ranitidin Helvepharm;Ranitidin Heumann;Ranitidin Hexal;Ranitidin Merck;Ranitidin Millet;Ranitidin NM;Ranitidin Normon;Ranitidin PB;Ranitidin Stada;Ranitidin von ct;Ranitidin-Cophar;Ranitidin-Isis;Ranitidin-ratiopharm;Ranitidina predilu Grif;Ranitidina Tamarang;Ranitiget;Ranitin;Ranitine;Ranobel;Rantacid;Ranuber;Raticina;Regalil;Renatac;Rozon;Rubiulcer;Santanol;Serviradine;Sostril;Tanidina;Taural;Terposen;Toriol;Trigger;Ulcecur;Ulcex;Ulcirex;Ulcodin;Ulcolind Rani;Ulsaven;Ultidine;Viserul;Zandid;Zantac;Zantac 150;Zantac 75;Zantac In Plastic Container;Zantarac;Zantic;

Ranitidine Base;Ranitidine HCL;Ranitidine hydrochloride;Rantidine HCL;

A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. [PubChem]

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• Amneal Pharmaceuticals
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Synthesis Reference	Not Available
General Reference	Not Available

Type	small molecule

Classes

Furans

Substructures

Ethers Oxoazaniums Nitro compounds Aliphatic and Aryl Amines Heterocyclic compounds Aromatic compounds Furans

gastric acid RELATED DISORDERS 中和胃酸;

Indication	Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Pharmacodynamics	Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.
Mechanism of action	The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.
Absorption	Approximately 50% bioavailability orally.
Volume of distribution	1.4 L/kg 1.76 L/kg [clinically significant renal function impairment (creatinine clearance 25 to 35 mL/min)]
Protein binding	15%
Metabolism	Hepatic. Ranitidine is metabolized to the N-oxide, S-oxide, and N-desmethyl metabolites, accounting for approximately 4%, 1%, and 1% of the dose, respectively.
Route of elimination	The principal route of excretion is the urine (active tubular excretion, renal clearance 410mL/min), with approximately 30% of the orally administered dose collected in the urine as unchanged drug in 24 hours.
Half life	2.8-3.1 hours
Clearance	29 mL/min [clinically significant renal function impairment] 3 mL/min/Kg [neonatal patients]
Toxicity	LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Affected organisms	Humans and other mammals
Pathways	Pathway Name SMPDB ID Ranitidine Pathway SMP00230

Properties
State	solid
Experimental Properties	Property Value Source melting point 69-70 °C PhysProp water solubility 24.7 mg/mL Not Available logP 0.27 SANGSTER (1993) Caco2 permeability -6.31 ADME Research, USCD
Predicted Properties	Property Value Source water solubility 7.95e-02 g/l ALOGPS logP 0.79 ALOGPS logP 0.98 ChemAxon logS -3.6 ALOGPS pKa (strongest basic) 8.08 ChemAxon physiological charge 1 ChemAxon hydrogen acceptor count 5 ChemAxon hydrogen donor count 2 ChemAxon polar surface area 86.26 ChemAxon rotatable bond count 10 ChemAxon refractivity 95.15 ChemAxon polarizability 33.58 ChemAxon

Drug	Interaction
Acenocoumarol	Ranitidine may increase the anticoagulant effect of acenocoumarol. (Conflicting evidence)
Anisindione	Ranitidine may increase the anticoagulant effect of anisindione. (Conflicting evidence)
Atazanavir	Ranitidine may decrease the levels/effects of atazanavir.
Cefditoren	H2-Antagonists such as ranitidine may decrease the serum concentration of cefditoren. Cefditoren prescribing information recommends to avoid concomitant use with H2-antagonists (eg, famotidine, ranitidine) and antacids as well. Consider alternative methods to minimize/control acid reflux (eg, diet modification) or alternative antimicrobial therapy if use of H2-antagonists can not be avoided.
Dabrafenib	H2-receptor antagonists may alter the solubility of dabrafenib and reduce its bioavailability.
Dasatinib	Ranitidine may decrease the serum level of dasatinib.
Dicumarol	Ranitidine may increase the anticoagulant effect of dicumarol. (Conflicting evidence)
Itraconazole	The H2-receptor antagonist, ranitidine, may decrease the absorption of itraconazole.
Ketoconazole	The H2-receptor antagonist, ranitidine, may decrease the absorption of ketoconazole.
Procainamide	The histamine H2-receptor antagonist, ranitidine, may increase the effect of procainamide.
Rilpivirine	Histamine-2 receptor antagonists increase gastric pH which causes a decrease in the exposure of rilpivirine thus reducing efficacy.
Tolazoline	Anticipated loss of efficacy of tolazoline
Vismodegib	Vismodegib serum concentrations may be decreased by histamine 2 receptor antagonists such as ranitidine.
Warfarin	Ranitidine may increase the anticoagulant effect of warfarin. (Conflicting evidence)

• Avoid alcohol.
• Avoid excessive quantities of coffee or tea (Caffeine).
• Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
• Take without regard to meals.