Acronize;Acronize PD;Aureocarmyl;Aureociclin;Aureociclina;Aureocina;Aureocycline;Aureomicina;Aureomycin;Aureomycin A-377;Aureomycin hydrochloride;Aureomycin monohydrochloride;Aureomykoin;Aurofac;Aurofac 10;Auxeomycin;B-Aureo;Biomitsin;Biomitsin hydrochloride;Biomycin A;Biomycin hydrochloride;Biovetin;Centraureo;Chrusomykine;Chrysomykine;Clorocipan;Duomycin;Flamycin;Isphamycin;Orospray;Psittacin hydrochloride;Tetra 5;Tetralysal;Tetrlysal 300;Tocopherex;

7-Chlorotetracycline;Chlorotetracycline;Chlorotetracycline hydrochloride;Chlortetracyclin;Chlortetracycline;Chlortetracycline hydrochloride;Chlortetracyclinium chloride;CLTC;

A tetracycline with a 7-chloro substitution. [PubChem]

• Lederle laboratories div american cyanamid co

Synthesis Reference	Not Available
General Reference	Link Meynadier J, Alirezai M: Systemic antibiotics for acne. Dermatology. 1998;196(1):135-9. Pubmed

Form	Route	Strength
Capsule	Oral

Type	small molecule

Classes

Tetracyclines Amino Acids

Substructures

Tetracyclines Hydroxy Compounds Benzyl Alcohols and Derivatives Naphthalenes Acetates Phenols and Derivatives Amino Ketones Aliphatic and Aryl Amines Benzene and Derivatives Carboxylic Acids and Derivatives Aminals and Derivatives Alcohols and Polyols Aromatic compounds Carboxamides and Derivatives Amino Acids Benzoyl Derivatives Cyclohexenes and Derivatives Phenyl Esters Enols Ketones

antibacterials 抗细菌;

Indication	For the treatment of infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Lymecycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease.
Pharmacodynamics	Lymecycline is a tetracycline broad-spectrum antibiotic. It is approximately 5000 times more soluble than tetracycline base and is unique amongst tetracyclines in that it is absorbed by the "active transport" process across the intestinal wall, making use of the same fast and efficient mechanism by which carbohydrates are absorbed. It inhibits cell growth by inhibiting translation.
Mechanism of action	Lymecycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Lymecycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Cells become resistant to lymecycline by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps lymecycline out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents lymecycline from acting on the ribosome.
Absorption	Absorption is fast and efficient. Bioavailability is 100% following oral administration.
Volume of distribution	Not Available
Protein binding	Not Available
Metabolism
Route of elimination	Not Available
Half life	Not Available
Clearance	Not Available
Toxicity	Adverse effects include nausea, vomiting, diarrhoea, glossitis, enterocolitis, dysphagia, dermatitis, hypersensitivity reactions, proctitis, and vaginitis.
Affected organisms	Enteric bacteria and other eubacteria
Pathways	Pathway Name SMPDB ID Lymecycline Pathway SMP00295

Properties
State	solid
Melting point	Not Available
Experimental Properties	Property Value Source water solubility Soluble (at all physiological pH values) PhysProp logP 0.3 PhysProp
Predicted Properties	Property Value Source water solubility 1.31e+00 g/l ALOGPS logP -0.27 ALOGPS logP -8.52 ChemAxon Molconvert logS -2.66 ALOGPS pKa 3.44 ChemAxon Molconvert hydrogen acceptor count 13 ChemAxon Molconvert hydrogen donor count 9 ChemAxon Molconvert polar surface area 242.98 ChemAxon Molconvert rotatable bond count 10 ChemAxon Molconvert refractivity 154.51 ChemAxon Molconvert polarizability 62.88 ChemAxon Molconvert

• Do not to take any indigestion remedies, iron or zinc supplements at the same time as this medicine.