药品详细
Proparacaine(丙美卡因)
化学结构式图
中文名
丙美卡因
英文名
Proparacaine
分子式
C16H26N2O3
化学名
2-(diethylamino)ethyl 3-amino-4-propoxybenzoate
分子量
Average: 294.3892
Monoisotopic: 294.194342708
Monoisotopic: 294.194342708
CAS号
499-67-2
ATC分类
S01H 局部麻醉药
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Proparacaine is a topical anesthetic drug of the amino ester group. It is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. [Wikipedia]
生产厂家
- Alcon laboratories inc
- Allergan pharmaceutical
- Apothecon inc div bristol myers squibb
- Bausch and lomb pharmaceuticals inc
- Optopics laboratories corp
- Pharmafair inc
- Sola barnes hind
- Taylor pharmacal co
封装厂家
- Accutome Inc.
- Akorn Inc.
- Alcon Laboratories
- Allergan Inc.
- Altaire Pharmaceuticals
- A-S Medication Solutions LLC
- Bausch & Lomb Inc.
- Conta Care Ophthalmics and Diagnostics
- Deca Pharmaceuticals LLC
- Diversified Healthcare Services Inc.
- Eye Care and Cure Corp.
- Eye Supply Usa Inc.
- Falcon Pharmaceuticals Ltd.
- Medical Ophthalmics
- MWI Veterinary Supply Co.
- Ocusoft
- Physicians Total Care Inc.
- Preferred Pharmaceuticals Inc.
- Professional Co.
- Rx Veterinary Products
- Stat Rx Usa
- Wa Butler Co.
- Wilson Ophthalmic Corp.
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | Used as a local (ophthalmic) anesthetic. | ||||||
| Pharmacodynamics | Proparacaine stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action. More specifically, proparacaine appears to bind or antagonize the function of voltage gated sodium channels. | ||||||
| Mechanism of action | The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. Proparacaine may alter epithelial sodium channels through interaction with channel protein residues. This limitation prevents the fundamental change necessary for the generation of the action potential. | ||||||
| Absorption | Not Available | ||||||
| Volume of distribution | Not Available | ||||||
| Protein binding | Not Available | ||||||
| Metabolism |
Plasma
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| Route of elimination | Not Available | ||||||
| Half life | Not Available | ||||||
| Clearance | Not Available | ||||||
| Toxicity | Not Available | ||||||
| Affected organisms |
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| Pathways |
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理化性质
| Properties | ||||||||||||||||||||||||||||||||||||||||
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| State | solid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
Not Available
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