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药品详细

Oxybuprocaine(奥布卡)

化学结构式图
中文名
奥布卡
英文名
Oxybuprocaine
分子式
C17H28N2O3
化学名
2-(diethylamino)ethyl 4-amino-3-butoxybenzoate
分子量
Average: 308.4158
Monoisotopic: 308.209992772
CAS号
99-43-4
ATC分类
D04A 未知;S01H 局部麻醉药
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Oxybuprocaine is the name of a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.

生产厂家
  • Sola barnes hind
封装厂家
参考
Synthesis Reference Not Available
General Reference Not Available
剂型
规格
化合物类型
Type small molecule
Classes
  • Aminobenzoates
Substructures
  • Aminobenzoates
  • Carboxylic Acids and Derivatives
  • Benzyl Alcohols and Derivatives
  • Acetates
  • Benzoates
  • Phenols and Derivatives
  • Aliphatic and Aryl Amines
  • Ethers
  • Benzene and Derivatives
  • Aromatic compounds
  • Anisoles
  • Benzoyl Derivatives
  • Phenyl Esters
  • Anilines
适应症
药理
Indication Used to temporarily numb the front surface of the eye so that the eye pressure can be measured or a foreign body removed.
Pharmacodynamics Oxybuprocaine is a local anaesthetic. It may be less irritating than tetracaine, and the onset and duration of action are similar to tetracaine.
Mechanism of action Oxybuprocaine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.
Absorption Not Available
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Pathways
Pathway Name SMPDB ID
Smp00400 Oxybuprocaine Pathway SMP00400
理化性质
Properties
State solid
Experimental Properties
Property Value Source
melting point 216.5 °C at 2.00E+00 mm Hg Not Available
water solubility Very soluble (hydrochloride salt) Not Available
logP 3.1 Not Available
Predicted Properties
Property Value Source
water solubility 5.44e-01 g/l ALOGPS
logP 3.3 ALOGPS
logP 3.05 ChemAxon
logS -2.8 ALOGPS
pKa (strongest acidic) 19.76 ChemAxon
pKa (strongest basic) 8.96 ChemAxon
physiological charge 1 ChemAxon
hydrogen acceptor count 4 ChemAxon
hydrogen donor count 1 ChemAxon
polar surface area 64.79 ChemAxon
rotatable bond count 11 ChemAxon
refractivity 90.64 ChemAxon
polarizability 35.83 ChemAxon
药物相互作用
食物相互作用
Not Available

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