Arkitropin;Camatropine;DL-Homatropine methyl bromide;DL-Methylbromide;Esopin;Homapin;Homatromide;Homatropine methyl bromide;Humulon lead salt;Hycodan, probilagol;Malcotran;Mesopin;Methyl Bromide Homatropine;Methylhomatropine;Methylhomatropine bromide;Novatrin;Novatrine;Novatropine;Npvatropine;Sed-tems;Sethyl;Tropinium methobromide mandelate;

Homatropine methylbromide is a quaternary ammonium muscarinic acetylcholine receptor antagonist belonging to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.

Synthesis Reference	Not Available
General Reference	Not Available

Unit description	Cost	Unit
Isopto homatropine 5% drops	6.41 USD	ml
Homatropine hbr 5% eye drop	6.06 USD	ml
Isopto homatropine 2% drops	5.57 USD	ml
Homatropaire 5% eye drops	3.82 USD	ml
Homatropine hbr crystals	2.69 USD	g
Hycodan tablet	1.4 USD	each

Type	small molecule

Classes

Phenylacetates Tropanes Alkaloids and Alkaloid Derivatives

Substructures

Carboxylic Acids and Derivatives Hydroxy Compounds Anions Benzyl Alcohols and Derivatives Acetates Phenylacetates Short-chain Hydroxy Acids Pyrrolidines Ethers Benzene and Derivatives Quaternary Ammonium Salts Heterocyclic compounds Aromatic compounds Tropanes Alcohols and Polyols Alkaloids and Alkaloid Derivatives Piperidines Cations

;gastric acid RELATED DISORDERS 中和胃酸;

Indication	Used in conjunction with antacids or histamine H2-receptor antagonists in the treatment of peptic ulcers, gastric ulcers and duodenal ulcers, to reduce further gastric acid secretion and delay gastric emptying.
Pharmacodynamics	Homatropine methylbromide belongs to the group of medicines called anti-muscarinics. Homatropine is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.
Mechanism of action	Homatropine is a quaternary ammonium muscarinic acetylcholine receptor antagonist. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Homatropine methylbromide inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves as well as on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These postganglionic receptor sites are present in the autonomic effector cells of the smooth muscle, cardiac muscle, sinoatrial and atrioventricular nodes, and exocrine glands. Depending on the dose, anticholinergics may reduce the motility and secretory activity of the gastrointestinal system, and the tone of the ureter and urinary bladder and may have a slight relaxant action on the bile ducts and gallbladder.
Absorption	Not Available
Volume of distribution	Not Available
Protein binding	Not Available
Metabolism
Route of elimination	Not Available
Half life	Not Available
Clearance	Not Available
Toxicity	Not Available
Affected organisms	Humans and other mammals
Pathways	Not Available

Properties
State	solid
Melting point	Not Available
Experimental Properties	Property Value Source logP 3.421 PhysProp
Predicted Properties	Property Value Source water solubility 5.20e-03 g/l ALOGPS logP -1.91 ALOGPS logP -2.57 ChemAxon Molconvert logS -4.85 ALOGPS pKa ChemAxon Molconvert hydrogen acceptor count 2 ChemAxon Molconvert hydrogen donor count 1 ChemAxon Molconvert polar surface area 46.53 ChemAxon Molconvert rotatable bond count 4 ChemAxon Molconvert refractivity 91.72 ChemAxon Molconvert polarizability 31.27 ChemAxon Molconvert

Drug	Interaction
Haloperidol	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Tacrine	The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Homatropine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Trimethobenzamide	Trimethobenzamide and Homatropine Methylbromide, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine	Triprolidine and Homatropine Methylbromide, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Trospium	Trospium and Homatropine Methylbromide, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.

Not Available