药品详细
Metixene (Metixene )
化学结构式图
中文名
Metixene
英文名
Metixene
分子式
Not Available
化学名
1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
分子量
Average: 309.468
Monoisotopic: 309.155120431
Monoisotopic: 309.155120431
CAS号
4969-02-2
ATC分类
N04A 未知
药物类型
small molecule
阶段
商品名
Atosil;Contalyl;Methixart;Tremaril;Tremaril hydrochloride;Tremonil;Trest;
同义名
Methixen [German];Methixene;Methixene hydrochloride;Metisene [DCIT];Metixene hydrochloride;Metixeno [INN-Spanish];Metixenum [INN-Latin];
基本介绍
Metixene (or methixene) is a anticholinergic used as an anti-parkinson drug. [Wikipedia]
生产厂家
- Novartis pharmaceuticals corp
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
|
| Substructures |
|
适应症
PARKINSON 帕金森氏症;
药理
| Indication | Used for the symptomatic treatment of parkinsonism. |
| Pharmacodynamics | Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued. |
| Mechanism of action | Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as metixene is considered to relate to competitive antagonism of acetylcholine at muscarinic receptors in the corpus striatum, which then restores the balance. |
| Absorption | Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Hepatic. Metabolism occurs via sulfoxydation and N-demethylation. |
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures. |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | liquid | ||||||||||||||||||||||||||||||||||||
| Melting point | < 25 oC | ||||||||||||||||||||||||||||||||||||
| Experimental Properties |
|
||||||||||||||||||||||||||||||||||||
| Predicted Properties |
|
||||||||||||||||||||||||||||||||||||
药物相互作用
食物相互作用
Not Available
收藏