药品详细
Lymecycline (Lymecycline )
化学结构式图
中文名
Lymecycline
英文名
Lymecycline
分子式
Not Available
化学名
(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid
分子量
Average: 602.6328
Monoisotopic: 602.258793456
Monoisotopic: 602.258793456
CAS号
992-21-2
ATC分类
J01A 未知
药物类型
small molecule
阶段
商品名
Acronize;Acronize PD;Aureocarmyl;Aureociclin;Aureociclina;Aureocina;Aureocycline;Aureomicina;Aureomycin;Aureomycin A-377;Aureomycin hydrochloride;Aureomycin monohydrochloride;Aureomykoin;Aurofac;Aurofac 10;Auxeomycin;B-Aureo;Biomitsin;Biomitsin hydrochloride;Biomycin A;Biomycin hydrochloride;Biovetin;Centraureo;Chrusomykine;Chrysomykine;Clorocipan;Duomycin;Flamycin;Isphamycin;Orospray;Psittacin hydrochloride;Tetra 5;Tetralysal;Tetrlysal 300;Tocopherex;
同义名
7-Chlorotetracycline;Chlorotetracycline;Chlorotetracycline hydrochloride;Chlortetracyclin;Chlortetracycline;Chlortetracycline hydrochloride;Chlortetracyclinium chloride;CLTC;
基本介绍
A tetracycline with a 7-chloro substitution. [PubChem]
生产厂家
- Lederle laboratories div american cyanamid co
封装厂家
参考
剂型
Form | Route | Strength |
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Capsule | Oral |
规格
化合物类型
Type | small molecule |
Classes |
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Substructures |
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适应症
antibacterials 抗细菌;
药理
Indication | For the treatment of infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Lymecycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease. | ||||||
Pharmacodynamics | Lymecycline is a tetracycline broad-spectrum antibiotic. It is approximately 5000 times more soluble than tetracycline base and is unique amongst tetracyclines in that it is absorbed by the "active transport" process across the intestinal wall, making use of the same fast and efficient mechanism by which carbohydrates are absorbed. It inhibits cell growth by inhibiting translation. | ||||||
Mechanism of action | Lymecycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Lymecycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Cells become resistant to lymecycline by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps lymecycline out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents lymecycline from acting on the ribosome. | ||||||
Absorption | Absorption is fast and efficient. Bioavailability is 100% following oral administration. | ||||||
Volume of distribution | Not Available | ||||||
Protein binding | Not Available | ||||||
Metabolism | |||||||
Route of elimination | Not Available | ||||||
Half life | Not Available | ||||||
Clearance | Not Available | ||||||
Toxicity | Adverse effects include nausea, vomiting, diarrhoea, glossitis, enterocolitis, dysphagia, dermatitis, hypersensitivity reactions, proctitis, and vaginitis. | ||||||
Affected organisms |
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Pathways |
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理化性质
Properties | |||||||||||||||||||||||||||||||||||||
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State | solid | ||||||||||||||||||||||||||||||||||||
Melting point | Not Available | ||||||||||||||||||||||||||||||||||||
Experimental Properties |
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Predicted Properties |
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药物相互作用
食物相互作用
- Do not to take any indigestion remedies, iron or zinc supplements at the same time as this medicine.