药品详细
Flucloxacillin (氟氯西林 )
化学结构式图
中文名
氟氯西林
英文名
Flucloxacillin
分子式
Not Available
化学名
(2S,5R,6R)-6-[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
分子量
Average: 453.872
Monoisotopic: 453.056147271
Monoisotopic: 453.056147271
CAS号
5250-39-5
ATC分类
J01C Beta-lactam Antibacterials, Penicillins
药物类型
small molecule
阶段
商品名
Floxapen;Fluclox;Sesamol;
同义名
Floxacillin;Flucloxacilina [INN-Spanish];Flucloxacillin Sodium;Flucloxacillin-Sodium;Flucloxacilline [INN-French];Flucloxacillinum [INN-Latin];
基本介绍
Antibiotic analog of cloxacillin. [PubChem]
生产厂家
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
antibacterials 抗细菌;
药理
| Indication | Used to treat bacterial infection by susceptible microorganisms. |
| Pharmacodynamics | Flucloxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Flucloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Flucloxacillin results from the inhibition of cell wall synthesis and is mediated through flucloxacillin binding to penicillin binding proteins (PBPs). Flucloxacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. |
| Mechanism of action | By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, flucloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that flucloxacillin interferes with an autolysin inhibitor. |
| Absorption | Bioavailability is 50鈥?0% following oral administration. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Hepatic. |
| Route of elimination | Not Available |
| Half life | 0.75鈥? hour |
| Clearance | Not Available |
| Toxicity | Not Available |
| Affected organisms |
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| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||
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| State | solid | ||||||||||||||||||||||||||||||||||||
| Melting point | Not Available | ||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Demeclocycline | Possible antagonism of action |
| Doxycycline | Possible antagonism of action |
| Ethinyl Estradiol | This anti-infectious agent could decrease the effect of the oral contraceptive |
| Mestranol | This anti-infectious agent could decrease the effect of the oral contraceptive |
| Methacycline | Possible antagonism of action |
| Methotrexate | The penicillin increases the effect and toxicity of methotrexate |
| Minocycline | Possible antagonism of action |
| Oxytetracycline | Possible antagonism of action |
| Rolitetracycline | Possible antagonism of action |
| Tetracycline | Possible antagonism of action |
食物相互作用
- Take on an empty stomach.
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