AB-PC;Ab-Pc Sol;Acillin;Adobacillin;Alpen;Amblosin;Amcill;Amfipen;Amfipen V;Amipenix S;Ampen;Ampi;Ampi-Bol;Ampi-Co;Ampi-Tab;Ampichel;Ampicil;Ampicillin A;Ampicin;Ampifarm;Ampikel;Ampimed;Ampipenin;Ampipenin, Nt3;Ampiscel;Ampisyn;Ampivax;Ampivet;Amplacilina;Amplin;Amplipenyl;Amplisom;Amplital;Ampy-Penyl;Austrapen;Binotal;Bonapicillin;Britacil;BRL;Campicillin;Cimex;Copharcilin;D-Cillin;Delcillin;Deripen;Divercillin;Doktacillin;Duphacillin;Geocillin;Grampenil;Guicitrina;Guicitrine;Lifeampil;Morepen;Norobrittin;Novo-Ampicillin;Nuvapen;Olin Kid;Omnipen;Omnipen-N;Orbicilina;Pen A;Pen a Oral;Pen Ampil;Penbristol;Penbritin;Penbritin Paediatric;Penbritin Syrup;Penbritin-S;Penbrock;Penicline;Penimic;Pensyn;Pentrex;Pentrexl;Pentrexyl;Pfizerpen A;Pfizerpen-A;Polycillin;Polycillin-N;Ponecil;Princillin;Principen;Principen '125';Principen '250';Principen '500';Qidamp;Racenacillin;Ro-Ampen;Rosampline;Roscillin;Semicillin;Semicillin R;Servicillin;Sk-Ampicillin;Spectrobid;Sumipanto;Supen;Synpenin;Texcillin;Tokiocillin;Tolomol;Totacillin;Totacillin-N;Totalciclina;Totapen;Trifacilina;Ultrabion;Ultrabron;Vampen;Viccillin;Viccillin S;Wypicil;

Aminobenzylpenicillin;Ampicilina [INN-Spanish];Ampicillin [Usan:Ban:Inn:Jan];Ampicillin Acid;Ampicillin Anhydrate;Ampicillin Anhydrous;Ampicillin Base;Ampicillin Sodium;Ampicillin Trihydrate;Ampicillina [Dcit];Ampicilline;Ampicilline [INN-French];Ampicillinum [INN-Latin];Anhydrous Ampicillin;Bayer 5427;D-Ampicillin;

Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. [PubChem]

• Acic fine chemicals inc
• American antibiotics llc
• Apothecon inc div bristol myers squibb
• Apothecon sub bristol myers squibb co
• Baxter healthcare corp anesthesia and critical care
• Bristol laboratories inc div bristol myers co
• Bristol myers squibb co
• Consolidated pharmaceutical group inc
• Dava pharmaceuticals inc
• Eli lilly and co
• Gc hanford manufacturing co
• Glaxosmithkline
• Instituto biochemico italiano spa
• International medication systems ltd
• Istituto biochimico italiano spa
• Ivax pharmaceuticals inc sub teva pharmaceuticals usa
• Lederle laboratories div american cyanamid co
• Marsam pharmaceuticals llc
• Mylan pharmaceuticals inc
• Parke davis div warner lambert co
• Pfizer laboratories div pfizer inc
• Purepac pharmaceutical co
• Sandoz inc
• Teva pharmaceuticals usa inc
• Vitarine pharmaceuticals inc
• Wyeth ayerst laboratories

• American Antibiotics LLC
• Apotheca Inc.
• APP Pharmaceuticals
• A-S Medication Solutions LLC
• Bryant Ranch Prepack
• C.O. Truxton Inc.
• Cardinal Health
• Carlisle Laboratories Inc.
• Central Texas Community Health Centers
• Claris Lifesciences Inc.
• Clonmel Healthcare Ltd.
• Comprehensive Consultant Services Inc.
• Comptoir Francaise De Productores
• Cura Pharmaceutical Co. Inc.
• Darby Dental Supply Co. Inc.
• DAVA Pharmaceuticals
• Dispensing Solutions
• Diversified Healthcare Services Inc.
• E.R. Squibb and Sons LLC
• GC Hanford Manufacturing Co.
• H and H Laboratories
• H.J. Harkins Co. Inc.
• Ibi Istituto Biochimico Italiano Giovanni Lorenzini SPA
• Major Pharmaceuticals
• Marnel Pharmaceuticals Inc.
• Mead Johnson and Co.
• Medpharm Inc.
• Nucare Pharmaceuticals Inc.
• Palmetto Pharmaceuticals Inc.
• Par Pharmaceuticals
• PCA LLC
• PD-Rx Pharmaceuticals Inc.
• Pharmedix
• Physicians Total Care Inc.
• Preferred Pharmaceuticals Inc.
• Prepackage Specialists
• Prescript Pharmaceuticals
• Putney Inc.
• Sagent Pharmaceuticals
• Sandhills Packaging Inc.
• Sandoz
• SC Antibiotice SA
• Signal Health Ltd.
• Southwood Pharmaceuticals
• Teva Pharmaceutical Industries Ltd.
• WG Critical Care LLC

Synthesis Reference	Not Available
General Reference	Not Available

Type	small molecule

Classes

Penicillins Phenethylamines

Substructures

Hydroxy Compounds Acetates Amino Ketones Aliphatic and Aryl Amines Benzene and Derivatives Carboxylic Acids and Derivatives Beta Lactams Penicillins Thiazoles Phenethylamines Heterocyclic compounds Aromatic compounds Carboxamides and Derivatives Lactams Azetidines Thiazolidines

antibacterials 抗细菌;

Indication	For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc
Pharmacodynamics	Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Ampicillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Ampicillin results from the inhibition of cell wall synthesis and is mediated through Ampicillin binding to penicillin binding proteins (PBPs). Ampicillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Mechanism of action	By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Ampicillin interferes with an autolysin inhibitor.
Absorption	Not Available
Volume of distribution	Not Available
Protein binding	Not Available
Metabolism	Not Available
Route of elimination	Ampicillin is excreted largely unchanged in the urine.
Half life	Not Available
Clearance	Not Available
Toxicity	Not Available
Affected organisms	Enteric bacteria and other eubacteria
Pathways	Not Available

Properties
State	solid
Experimental Properties	Property Value Source melting point 208 dec °C PhysProp water solubility 1.01E+004 mg/L (at 21 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992) logP 1.35 SANGSTER (1994)
Predicted Properties	Property Value Source water solubility 6.05e-01 g/l ALOGPS logP 0.88 ALOGPS logP -2 ChemAxon logS -2.8 ALOGPS pKa (strongest acidic) 3.24 ChemAxon pKa (strongest basic) 7.44 ChemAxon physiological charge 0 ChemAxon hydrogen acceptor count 5 ChemAxon hydrogen donor count 3 ChemAxon polar surface area 112.73 ChemAxon rotatable bond count 4 ChemAxon refractivity 87.52 ChemAxon polarizability 34.54 ChemAxon

Drug	Interaction
Atenolol	Ampicillin decreases bioavailability of atenolol
Demeclocycline	Possible antagonism of action
Doxycycline	Possible antagonism of action
Ethinyl Estradiol	This anti-infectious agent could decrease the effect of the oral contraceptive
Mestranol	This anti-infectious agent could decrease the effect of the oral contraceptive
Methacycline	Possible antagonism of action
Methotrexate	The penicillin increases the effect and toxicity of methotrexate
Minocycline	Possible antagonism of action
Oxytetracycline	Possible antagonism of action
Rolitetracycline	Possible antagonism of action
Tetracycline	Possible antagonism of action

• Take on an empty stomach.