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药品详细

Cefpiramide(头孢匹胺)

化学结构式图
中文名
头孢匹胺
英文名
Cefpiramide
分子式
C25H24N8O7S2
化学名
(6R,7R)-7-[(2R)-2-[(4-hydroxy-6-methylpyridin-3-yl)formamido]-2-(4-hydroxyphenyl)acetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
分子量
Average: 612.637
Monoisotopic: 612.120936542
CAS号
70797-11-4
ATC分类
J01D Other Beta- lactam Antibacterials
药物类型
small molecule
阶段
approved
商品名
Cefpiramide [USAN:INN];Cefpiramide Sodium;Cefpiramido [INN-Spanish];Cefpiramidum [INN-Latin];
同义名
SM-1652;
基本介绍

Cefpiramide is a third-generation cephalosporin antibiotic.

生产厂家
  • Wyeth ayerst laboratories
封装厂家
参考
Synthesis Reference Not Available
General Reference
  1. Wang H, Yu Y, Xie X, Wang C, Zhang Y, Yuan Y, Zhang X, Liu J, Wang P, Chen M: In-vitro antibacterial activities of cefpiramide and other broad-spectrum antibiotics against 440 clinical isolates in China. J Infect Chemother. 2000 Jun;6(2):81-5. Pubmed
  2. Iakovlev VP, Vishnevskii VA, Khlebnikov EP, Khadin IM, Plavlova MV, Elagina LV, Izotova GN: [Cefpiramide (Tamicin) in the treatment of purulent complications of abdominal surgery] Antibiot Khimioter. 1995 Sep;40(9):30-4. Pubmed
  3. Sampi K, Hattori M: [Comparative study of cefpiramide + amikacin versus piperacillin + amikacin in granulocytopenic patients: a randomized, prospective study] Gan To Kagaku Ryoho. 1992 Aug;19(9):1315-20. Pubmed
剂型
规格
化合物类型
Type small molecule
Classes Not Available
Substructures Not Available
适应症
antibacterials 抗细菌;
药理
Indication For treatment of severe infections caused by susceptible bacteria such as P. aeruginosa.
Pharmacodynamics Cefpiramide is a cephalosporin active against Pseudomonas aeruginosa. It has a broad spectrum of antibacterial activity. Cefpiramide works by inhibiting bacterial cell wall biosynthesis. The plasma half-lives of cefpiramide in rabbits, dogs, and rhesus monkeys were much longer than those of cefoperazone and cefazolin.
Mechanism of action The bactericidal activity of cefpiramide results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Absorption Rapidly absorbed following intramuscular injection.
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Not Available
Route of elimination Not Available
Half life 4.44 hours
Clearance Not Available
Toxicity Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Affected organisms
  • Enteric bacteria and other eubacteria
Pathways Not Available
理化性质
Properties
State solid
Experimental Properties
Property Value Source
logP -0.9 Not Available
Predicted Properties
Property Value Source
water solubility 6.68e-02 g/l ALOGPS
logP 0.53 ALOGPS
logP 0.22 ChemAxon
logS -4 ALOGPS
pKa (strongest acidic) 3.47 ChemAxon
pKa (strongest basic) 2.66 ChemAxon
physiological charge -1 ChemAxon
hydrogen acceptor count 11 ChemAxon
hydrogen donor count 5 ChemAxon
polar surface area 212.76 ChemAxon
rotatable bond count 9 ChemAxon
refractivity 164.81 ChemAxon
polarizability 58.79 ChemAxon
药物相互作用
食物相互作用
Not Available

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