药品详细
Fosfomycin (磷霉素 )
化学结构式图
中文名
磷霉素
英文名
Fosfomycin
分子式
Not Available
化学名
[(2R,3S)-3-methyloxiran-2-yl]phosphonic acid
分子量
Average: 138.059
Monoisotopic: 138.008195224
Monoisotopic: 138.008195224
CAS号
23155-02-4
ATC分类
J01X Other Antibacterials
药物类型
small molecule
阶段
商品名
Monurol;Veramina;
同义名
Fosfocina;Fosfomycin disodium salt;Fosfomycin sodium;Fosfonomycin;Phosphomycin;phosphomycin disodium salt;Phosphonomycin;
基本介绍
An antibiotic produced by Streptomyces fradiae. [PubChem]
生产厂家
- Zambon spa italy
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
| Form | Route | Strength |
|---|---|---|
| Powder | Oral |
规格
| Unit description | Cost | Unit |
|---|---|---|
| Monurol 3 gm Packets | 50.87 USD | packet |
| Monurol 3 gm sachet | 47.07 USD | each |
| Viramune 200 mg tablet | 9.48 USD | tablet |
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
antibacterials 抗细菌;
药理
| Indication | For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis. |
| Pharmacodynamics | Fosfomycin is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Fosfomycin also reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. |
| Mechanism of action | Fosfomycin is a phosphoenolpyruvate analogue produced by Streptomyces that irreversibly inhibits enolpyruvate transferase (MurA), which prevents the formation of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall. |
| Absorption | Fosfomycin tromethamine is rapidly absorbed following oral administration and converted to fosfomycin. Oral bioavailability under fasting conditions is 37%. When given with food, oral bioavailability is reduced to 30% |
| Volume of distribution |
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| Protein binding | 0% (not bound to plasma proteins) |
| Metabolism |
No transformation, excreted unchanged |
| Route of elimination | Fosfomycin is excreted unchanged in both urine and feces. |
| Half life | 5.7 (± 2.8) hours. The elimination half-life is 40 hours in anuric patients undergoing hemodialysis. |
| Clearance |
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| Toxicity | LD50>5 g/kg (rats). Side effects may include diarrhea |
| Affected organisms |
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| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||
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| State | solid | ||||||||||||||||||||||||||||||||||||
| Melting point | 94 oC | ||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
- Food decreases Cmax slightly.
- Take without regard to meals.
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