药品详细
Sulfapyridine(磺胺吡啶)
化学结构式图
中文名
磺胺吡啶
英文名
Sulfapyridine
分子式
C11H11N3O2S
化学名
4-amino-N-(pyridin-2-yl)benzene-1-sulfonamide
分子量
Average: 249.289
Monoisotopic: 249.057197301
Monoisotopic: 249.057197301
CAS号
144-83-2
ATC分类
J01E 未知
药物类型
small molecule
阶段
approved
商品名
Adiplon;Coccoclase;Dagenan;Eubasin;Eubasinum;Haptocil;M and B 693;Piridazol;Plurazol;Pyriamid;Pyridazol;Relbapiridina;Ronin;Septipulmon;Streptosilpyridine;Sulfidin;Sulfidine;Thioseptal;Trianon;
同义名
2-Sulfanilamidopyridin;2-Sulfanilamidopyridine;2-Sulfanilylaminopyridine;2-Sulfapyridine;4-(2-Pyridinylsulfonyl)aniline;4-[(2-Pyridylamino)sulfonyl]aniline;N-2-Pyridylsulfanilamide;N(sup 1)-2-Pyridylsulfanilamide;N(sup1)-Pyridylsulfanilamide;N1-2-Pyridylsulfanilamide;Sulphapyridine;
基本介绍
Antibacterial, potentially toxic, used to treat certain skin diseases. [PubChem]
生产厂家
- Eli lilly and co
封装厂家
- Amend
- Prime European Therapeuticals SPA
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
antibacterials 抗细菌;
药理
| Indication | For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid and pyoderma gangrenosum |
| Pharmacodynamics | Sulfapyridine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus. |
| Mechanism of action | Sulfapyridine is a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid by means of processing the substrate para-aminobenzoic acid (PABA). Dihydropteroate synthetase activity is vital in the synthesis of folate, and folate is required for cells to make nucleic acids, such as DNA or RNA. So if DNA molecules cannot be built, the cell cannot divide. |
| Absorption | Approximately 60-80% |
| Volume of distribution | Not Available |
| Protein binding | Approximately 50% bound to plasma proteins. |
| Metabolism |
Hepatic.
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| Route of elimination | Not Available |
| Half life | 6-14 hours. |
| Clearance | Not Available |
| Toxicity | LD50 is 15800 mg/kg (orally in rats). |
| Affected organisms |
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| Pathways | Not Available |
理化性质
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Chlorpropamide | Sulfonamide/sulfonylurea: possible hypoglycemia |
| Methotrexate | The sulfamide increases the toxicity of methotrexate |
食物相互作用
Not Available
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