药品详细
Spectinomycin(大观霉素)
化学结构式图
中文名
大观霉素
英文名
Spectinomycin
分子式
C14H24N2O7
化学名
(1R,3S,5R,8R,10R,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.0^{3,8}]tetradecan-7-one
分子量
Average: 332.3496
Monoisotopic: 332.158351132
Monoisotopic: 332.158351132
CAS号
1695-77-8
ATC分类
J01X Other Antibacterials
药物类型
small molecule
阶段
approved
商品名
Actinospectacin;Spectam;Togamycin;Trobicin;
同义名
Actinospectacina [Italian];Antibiotic 2233wp;Espectinomicina [INN-Spanish];SCM;Spectinomicina [Italian];Spectinomycin Di HCl;Spectinomycin HCl/ Sulphate;Spectinomycine [INN-French];Spectinomycinum [INN-Latin];
基本介绍
An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.
生产厂家
- Pharmacia and upjohn co
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
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| Substructures |
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适应症
antibacterials 抗细菌;
药理
| Indication | For use in the treatment of acute gonorrheal urethritis and proctitis in the male and acute gonorrheal cervicitis and proctitis in the female when due to susceptible strains of Neisseria gonorrhoeae. | ||||||
| Pharmacodynamics | Spectinomycin is an aminocyclitol antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure. | ||||||
| Mechanism of action | Spectinomycin is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. It is bactericidal in its action. | ||||||
| Absorption | Rapidly and almost completely absorbed after intramuscular injection. | ||||||
| Volume of distribution | Not Available | ||||||
| Protein binding | Not significant | ||||||
| Metabolism |
Not Available
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| Route of elimination | Not Available | ||||||
| Half life | 1 to 3 hours in patients with normal renal function and 10 to 30 hours in patients with impaired renal function with a creatinine clearance < 20 mL per minute. | ||||||
| Clearance | Not Available | ||||||
| Toxicity | Acute oral toxicity (LD50): >5000 mg/kg [Rat]. Information on overdosage in humans is not available. | ||||||
| Affected organisms |
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理化性质
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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药物相互作用
食物相互作用
Not Available
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