药品详细
Azlocillin(阿洛西林)
化学结构式图
中文名
阿洛西林
英文名
Azlocillin
分子式
C20H23N5O6S
化学名
(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2R)-2-{[(2-oxoimidazolidin-1-yl)carbonyl]amino}-2-phenylacetamido]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
分子量
Average: 461.492
Monoisotopic: 461.136904183
Monoisotopic: 461.136904183
CAS号
37091-66-0
ATC分类
J01C Beta-lactam Antibacterials, Penicillins
药物类型
small molecule
阶段
approved
商品名
Azlin;Bayer Brand of Azlocillin;Securopen;
同义名
Azlocilina [INN-Spanish];Azlocillin sodium salt;Azlocilline [INN-French];Azlocillinum [INN-Latin];
基本介绍
A semisynthetic ampicillin-derived acylureido penicillin. [PubChem]
生产厂家
- Bayer pharmaceuticals corp
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference |
|
剂型
规格
化合物类型
| Type | small molecule |
| Classes | Not Available |
| Substructures | Not Available |
适应症
antibacterials 抗细菌;
药理
| Indication | For the treatment of infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae. |
| Pharmacodynamics | Azlocillin, similar to mezlocillin and piperacillin, is an acylampicillin with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. Azlocillin demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa, and, in contrast to most cephalosporins, exhibits activity against enterococci. |
| Mechanism of action | By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, azlocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that azlocillin interferes with an autolysin inhibitor. |
| Absorption | Not significantly absorbed from the gastrointestinal tract. |
| Volume of distribution | Not Available |
| Protein binding | 20 to 46% bound to plasma proteins |
| Metabolism |
Eliminated predominantly by renal mechanisms, but also undergoes biotransformation within body tissues and intraintestinal degradation by bowel bacteria, with high concentrations found in bile.
|
| Route of elimination | Not Available |
| Half life | Mean elimination half-life is 1.3 to 1.5 hours. Longer in neonates, and 2 to 6 hours in patients with renal impairment. |
| Clearance | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
|
||||||||||||||||||||||||||||||||||||||||||
| Predicted Properties |
|
||||||||||||||||||||||||||||||||||||||||||
药物相互作用
| Drug | Interaction |
|---|---|
| Demeclocycline | Possible antagonism of action |
| Doxycycline | Possible antagonism of action |
| Ethinyl Estradiol | This anti-infectious agent could decrease the effect of the oral contraceptive |
| Minocycline | Possible antagonism of action |
| Tetracycline | Possible antagonism of action |
食物相互作用
Not Available
收藏