药品详细
Cefadroxil(头孢羟氨苄)
化学结构式图
中文名
头孢羟氨苄
英文名
Cefadroxil
分子式
C16H17N3O5S
化学名
(6R,7R)-7-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
分子量
Average: 363.388
Monoisotopic: 363.088891359
Monoisotopic: 363.088891359
CAS号
66592-87-8
ATC分类
J01D Other Beta- lactam Antibacterials
药物类型
small molecule
阶段
approved
商品名
Baxan;Bidocef;Cefa-Drops;Cefamox;Cephos;Duracef;Kefroxil;Oracefal;Sedral;Sumacef;Ultracef;
同义名
CDX;Cefadroxil Monohydrate;Cefradroxil;
基本介绍
Long-acting, broad-spectrum, water-soluble, cephalexin derivative. [PubChem]
生产厂家
- Apothecon inc div bristol myers squibb
- Aurobindo pharma ltd
- Bristol laboratories inc div bristol myers co
- Hikma pharmaceuticals
- Ivax pharmaceuticals inc sub teva pharmaceuticals usa
- Lupin ltd
- Orchid healthcare
- Purepac pharmaceutical co
- Ranbaxy laboratories ltd
- Ranbaxy pharmaceuticals inc
- Sandoz inc
- Teva pharmaceuticals usa
- Teva pharmaceuticals usa inc
- Warner chilcott inc
封装厂家
- Aidarex Pharmacuticals LLC
- Apothecon
- A-S Medication Solutions LLC
- Aurobindo Pharma Ltd.
- Barr Pharmaceuticals
- Bristol-Myers Squibb Co.
- Bryant Ranch Prepack
- Dispensing Solutions
- Diversified Healthcare Services Inc.
- Greenstone LLC
- H.J. Harkins Co. Inc.
- Hikma Pharmaceuticals
- Innoviant Pharmacy Inc.
- Institut Biochemique SA
- Jazeera Pharmaceutical Industries
- Lupin Pharmaceuticals Inc.
- Major Pharmaceuticals
- Murfreesboro Pharmaceutical Nursing Supply
- Northstar Rx LLC
- Nucare Pharmaceuticals Inc.
- Orchid Healthcare
- Palmetto Pharmaceuticals Inc.
- PCA LLC
- PD-Rx Pharmaceuticals Inc.
- Pharmaceutical Utilization Management Program VA Inc.
- Pharmedix
- Physicians Total Care Inc.
- Preferred Pharmaceuticals Inc.
- Prescript Pharmaceuticals
- Prescription Dispensing Service Inc.
- Putney Inc.
- Ranbaxy Laboratories
- Rebel Distributors Corp.
- Redpharm Drug
- Sandoz
- Southwood Pharmaceuticals
- Teva Pharmaceutical Industries Ltd.
- Warner Chilcott Co. Inc.
- West-Ward Pharmaceuticals
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes | Not Available |
| Substructures | Not Available |
适应症
antibacterials 抗细菌;
药理
| Indication | For the treatment of the following infections (skin, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Streptococcus pyogenes |
| Pharmacodynamics | Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis. |
| Mechanism of action | Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor. |
| Absorption | Cefadroxil is well absorbed on oral administration; food does not interfere with its absorption. |
| Volume of distribution | Not Available |
| Protein binding | Binding rates of cefadroxil were 28.1% by U.F. method |
| Metabolism |
Not Available
|
| Route of elimination | Over 90% of the drug is excreted unchanged in the urine within 24 hours. It crosses the placenta and appears in breast milk. |
| Half life | 1.5 hours |
| Clearance | Not Available |
| Toxicity | Nausea, vomiting, diarrhoea, allergic rashes may occur |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||||||||
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Probenecid | Probenecid may increase the serum level of cefadroxil. |
食物相互作用
- Food may reduce the digestive problems that sometimes occur.
- Take without regard to meals.
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