药品详细
Hetacillin (Hetacillin )
化学结构式图
中文名
Hetacillin
英文名
Hetacillin
分子式
Not Available
化学名
(2S,5R,6R)-6-[(4R)-2,2-dimethyl-5-oxo-4-phenylimidazolidin-1-yl]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
分子量
Average: 389.469
Monoisotopic: 389.140926929
Monoisotopic: 389.140926929
CAS号
3511-16-8
ATC分类
J01C Beta-lactam Antibacterials, Penicillins
药物类型
small molecule
阶段
商品名
Hetacillin potassium;Versapen;Versapen-k;
同义名
基本介绍
Hetacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name “penicillin” can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Hetacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Hetacillin results from the inhibition of cell wall synthesis and is mediated through Hetacillin binding to penicillin binding proteins (PBPs).
生产厂家
- Bristol laboratories inc div bristol myers co
封装厂家
参考
Synthesis Reference | Not Available |
General Reference | Not Available |
剂型
规格
化合物类型
Type | small molecule |
Classes |
|
Substructures |
|
适应症
antibacterials 抗细菌;
药理
Indication | Hetacillin is a beta-lactam antibiotic prodrug used to treat bacterial infections. In the body it gets converted to ampicillin. |
Pharmacodynamics | Hetacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Hetacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Hetacillin results from the inhibition of cell wall synthesis and is mediated through Hetacillin binding to penicillin binding proteins (PBPs). |
Mechanism of action | Hetacillin is a semisynthetic penicillin prodrug which itself has no antibacterial activity, but is converted in the body to ampicillin and has actions and uses similar to those of ampicillin. Hetacillin is prepared by reacting ampicillin with acetone. Ampicillin rapidly decomposes because of the intramolecular attack of the side chain amino group on the lactam ring. Hetacillin locks up the offending amino group and prevents the decompolsition Hetacillin, once hydrolyzed to ampicillin (and acetone) binds to the penicillin binding proteins found in susceptible bacteria. This inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. Targets below reflect ampicillin targets. |
Absorption | Not Available |
Volume of distribution | Not Available |
Protein binding | Not Available |
Metabolism |
Hydrolyzed to active ampicillin via esterases |
Route of elimination | Not Available |
Half life | Not Available |
Clearance | Not Available |
Toxicity | Not Available |
Affected organisms |
|
Pathways | Not Available |
理化性质
Properties | |||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
State | solid | ||||||||||||||||||||||||||||||||||||
Melting point | 190 oC | ||||||||||||||||||||||||||||||||||||
Experimental Properties |
|
||||||||||||||||||||||||||||||||||||
Predicted Properties |
|
药物相互作用
Drug | Interaction |
---|---|
Demeclocycline | Possible antagonism of action |
Doxycycline | Possible antagonism of action |
Ethinyl Estradiol | This anti-infectious agent could decrease the effect of the oral contraceptive |
Minocycline | Possible antagonism of action |
Tetracycline | Possible antagonism of action |
食物相互作用
Not Available