药品详细
Oxacillin(苯唑西林)
化学结构式图
中文名
苯唑西林
英文名
Oxacillin
分子式
C19H19N3O5S
化学名
(2S,5R,6R)-3,3-dimethyl-6-(5-methyl-3-phenyl-1,2-oxazole-4-amido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
分子量
Average: 401.436
Monoisotopic: 401.104541423
Monoisotopic: 401.104541423
CAS号
66-79-5
ATC分类
J01C Beta-lactam Antibacterials, Penicillins;J01C Beta-lactam Antibacterials, Penicillins;J01C Beta-lactam Antibacterials, Penicillins;J01C Beta-lactam Antibacterials, Penicillins
药物类型
small molecule
阶段
approved
商品名
Bactocill;
同义名
Oxacillin Sodium;
基本介绍
An antibiotic similar to flucloxacillin used in resistant staphylococci infections. [PubChem]
生产厂家
- Apothecon inc div bristol myers squibb
- Apothecon sub bristol myers squibb co
- Baxter healthcare corp
- Elkins sinn div ah robins co inc
- Glaxosmithkline
- Istituto biochimico italiano spa
- Marsam pharmaceuticals llc
- Sandoz inc
- Teva pharmaceuticals usa inc
- Watson laboratories inc
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
antibacterials 抗细菌;
药理
| Indication | Used in the treatment of resistant staphylococci infections. |
| Pharmacodynamics | Oxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Oxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Oxacillin results from the inhibition of cell wall synthesis and is mediated through Oxacillin binding to penicillin binding proteins (PBPs). Oxacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. |
| Mechanism of action | By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Oxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Oxacillin interferes with an autolysin inhibitor. |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | 94.2 +/- 2.1% (binds to serum protein, mainly albumin) |
| Metabolism |
Not Available
|
| Route of elimination | Oxacillin Sodium is rapidly excreted as unchanged drug in the urine by glomerular filtration and active tubular secretion. |
| Half life | 20 to 30 minutes |
| Clearance | Not Available |
| Toxicity | Not Available |
| Affected organisms |
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| Pathways | Not Available |
理化性质
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Demeclocycline | Possible antagonism of action |
| Doxycycline | Possible antagonism of action |
| Ethinyl Estradiol | This anti-infectious agent could decrease the effect of the oral contraceptive |
| Minocycline | Possible antagonism of action |
| Tetracycline | Possible antagonism of action |
食物相互作用
Not Available
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