药品详细
Cefprozil(头孢丙烯)
化学结构式图
中文名
头孢丙烯
英文名
Cefprozil
分子式
C18H19N3O5S
化学名
(6R,7R)-7-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
分子量
Average: 389.426
Monoisotopic: 389.104541423
Monoisotopic: 389.104541423
CAS号
92665-29-7
ATC分类
J01D Other Beta- lactam Antibacterials
药物类型
small molecule
阶段
approved
商品名
Arzimol;Brisoral;Cronocef;Procef;Serozil;
同义名
Cefprozil anhydrous;Cefprozilo [INN-Spanish];Cefprozilum [INN-Latin];
基本介绍
Cefprozil is a cephalosporin antibiotic. It can be used to treat bronchitis, ear infections, skin infections, and other bacterial infections.
生产厂家
- Apotex inc
- Aurobindo pharma ltd
- Aurobindo pharma ltd inc
- Bristol myers squibb co pharmaceutical research institute
- Lupin ltd
- Orchid healthcare
- Ranbaxy laboratories ltd
- Sandoz inc
- Teva pharmaceuticals usa
- Teva pharmaceuticals usa inc
- Wockhardt ltd
封装厂家
- Apotex Inc.
- A-S Medication Solutions LLC
- Aurobindo Pharma Ltd.
- Bristol-Myers Squibb Co.
- Dispensing Solutions
- Greenstone LLC
- Howard Beach Medical Equipment
- Lupin Pharmaceuticals Inc.
- Northstar Rx LLC
- Orchid Healthcare
- PD-Rx Pharmaceuticals Inc.
- Pharmaceutical Utilization Management Program VA Inc.
- Physicians Total Care Inc.
- Ranbaxy Laboratories
- Redpharm Drug
- Sandoz
- Southwood Pharmaceuticals
- Teva Pharmaceutical Industries Ltd.
- Wockhardt Ltd.
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes | Not Available |
| Substructures | Not Available |
适应症
antibacterials 抗细菌;
药理
| Indication | For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph |
| Pharmacodynamics | Cefprozil, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections, and respiratory tract infections. |
| Mechanism of action | Cefprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefprozil interferes with an autolysin inhibitor. |
| Absorption | Oral bioavailability is approximately 95%. |
| Volume of distribution |
|
| Protein binding | 36% |
| Metabolism |
Cefprozil is eliminated primarily by the kidneys
|
| Route of elimination | Not Available |
| Half life | 1.3 hours |
| Clearance |
|
| Toxicity | Single 5000 mg/kg oral doses of cefprozil caused no mortality or signs of toxicity in adult, weaning or neonatal rats, or adult mice. A single oral dose of 3000 mg/kg caused diarrhea and loss of appetite in cynomolgus monkeys, but no mortality. |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||||||||
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Probenecid | Probenecid may increase the serum level of cefprozil. |
食物相互作用
- Take without regard to meals.
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