药品详细
Cefalotin(头孢噻吩)
化学结构式图
中文名
头孢噻吩
英文名
Cefalotin
分子式
C16H16N2O6S2
化学名
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
分子量
Average: 396.438
Monoisotopic: 396.044977634
Monoisotopic: 396.044977634
CAS号
153-61-7
ATC分类
J01D Other Beta- lactam Antibacterials
药物类型
small molecule
阶段
approved
商品名
Averon-1;Cemastin;Coaxin;Keflin;Seffin;
同义名
Cefalothin;Cefalotina [INN-Spanish];Cefalotine [INN-French];Cefalotinum [INN-Latin];Cephalothin;Cephalothin Sodium;Cephalothinum;Cephalotin;CLS;
基本介绍
A cephalosporin antibiotic. [PubChem]
生产厂家
- Abbott laboratories pharmaceutical products div
- Abraxis pharmaceutical products
- Baxter healthcare corp
- Bristol laboratories inc div bristol myers co
- Eli lilly and co
- Glaxosmithkline
- International medication systems ltd
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
antibacterials 抗细菌;
药理
| Indication | Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract. |
| Pharmacodynamics | Cefalotin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally. |
| Mechanism of action | The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall compenent from being properly synthesized. |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | 65-80% |
| Metabolism |
Metabolized to a less active desacetyl metabolite, although 50-75% of the drug is eliminated unchanged in the urine.
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| Route of elimination | Not Available |
| Half life | 30 minutes |
| Clearance | Not Available |
| Toxicity | Rat intravenous LD50 is 4000 mg/kg. |
| Affected organisms |
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| Pathways | Not Available |
理化性质
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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