药品详细
Cefpodoxime (头孢 )
化学结构式图
中文名
头孢
英文名
Cefpodoxime
分子式
Not Available
化学名
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
分子量
Average: 427.455
Monoisotopic: 427.062024681
Monoisotopic: 427.062024681
CAS号
82619-04-3
ATC分类
J01D Other Beta- lactam Antibacterials
药物类型
small molecule
阶段
商品名
Banan;Doxef;Vantin;
同义名
Cefpodoxime proxetil;CPDX-PR;RU 51807;
基本介绍
Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
生产厂家
- Aurobindo pharma ltd
- Orchid healthcare
- Pharmacia and upjohn co
- Ranbaxy laboratories ltd
- Sandoz inc
- Sankyo usa corp
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
| Form | Route | Strength |
|---|---|---|
| Granule, for suspension | Oral | |
| Tablet, film coated | Oral |
规格
| Unit description | Cost | Unit |
|---|---|---|
| Vantin 20 200 mg tablet Bottle | 194.37 USD | bottle |
| Vantin 20 100 mg tablet Bottle | 137.26 USD | bottle |
| Vantin 100 mg/5ml Suspension 100ml Bottle | 133.84 USD | bottle |
| Vantin 50 mg/5ml Suspension 100ml Bottle | 70.34 USD | bottle |
| Vantin 50 mg/5ml Suspension 50ml Bottle | 36.95 USD | bottle |
| Vantin 200 mg tablet | 9.67 USD | tablet |
| Cefpodoxime Proxetil 200 mg tablet | 7.02 USD | tablet |
| Cefpodoxime 200 mg tablet | 6.41 USD | tablet |
| Vantin 100 mg tablet | 6.33 USD | tablet |
| Cefpodoxime 100 mg tablet | 5.11 USD | tablet |
化合物类型
| Type | small molecule |
| Classes |
|
| Substructures |
|
适应症
antibacterials 抗细菌;
药理
| Indication | For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms. |
| Pharmacodynamics | Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis. |
| Mechanism of action | Cefpodoxime is active against a wide spectrum of Gram-positive and Gram-negative bacteria. Cefpodoxime is stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and cephalosporins, due to their production of beta-lactamase, may be susceptible to cefpodoxime. Cefpodoxime is inactivated by certain extended spectrum beta-lactamases. The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis. The active metabolite of cefpodoxime binds preferentially to penicillin binding protein 3, which inhibits production of peptidoglycan, the primary constituent of bacterial cell walls. |
| Absorption | Cefpodoxime proxetil is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Following oral administration of 100 mg of cefpodoxime proxetil to fasting subjects, approximately 50% of the administered cefpodoxime dose was absorbed systemically. |
| Volume of distribution | Not Available |
| Protein binding | 22 to 33% in serum and from 21 to 29% in plasma. |
| Metabolism | |
| Route of elimination | Over the recommended dosing range (100 to 400 mg), approximately 29 to 33% of the administered cefpodoxime dose was excreted unchanged in the urine in 12 hours. |
| Half life | 2.09 to 2.84 hours |
| Clearance | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | solid | ||||||||||||||||||||||||||||||||||||
| Melting point | Not Available | ||||||||||||||||||||||||||||||||||||
| Experimental Properties | Not Available | ||||||||||||||||||||||||||||||||||||
| Predicted Properties |
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药物相互作用
食物相互作用
- Take on empty stomach: 1 hour before or 2 hours after meals.
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