药品详细
Temafloxacin (Temafloxacin )
化学结构式图
中文名
Temafloxacin
英文名
Temafloxacin
分子式
Not Available
化学名
1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
分子量
Average: 417.3811
Monoisotopic: 417.130026072
Monoisotopic: 417.130026072
CAS号
108319-06-8
ATC分类
J01M 未知
药物类型
small molecule
阶段
商品名
Omniflox;
同义名
Temafloxacin hydrochloride;Temafloxacina [spanish];Temafloxacine [french];Temafloxacinum [latin];
基本介绍
Temafloxacin is a fluoroquinolone antibiotic drug which was withdrawn from sale in the U.S. shortly after its approval in 1992 because of serious adverse reactions resulting in three deaths. [Wikipedia]
生产厂家
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
|
| Substructures |
|
适应症
antibacterials 抗细菌;
药理
| Indication | For the treatment of lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections. |
| Pharmacodynamics | Temafloxacin (marketed by Abbott Laboratories as Omniflox), is a fluoroquinolone antibiotic drug which was withdrawn from sale in the U.S. shortly after its approval in 1992 because of serious adverse reactions resulting in three deaths. Flouroquinolones such as lomefloxacin possess excellent activity against gram-negative aerobic bacteria such as E.coli and Neisseria gonorrhoea as well as gram-positive bacteria including S. pneumoniae and Staphylococcus aureus. They also posses effective activity against shigella, salmonella, campylobacter, gonococcal organisms, and multi drug resistant pseudomonas and enterobacter. |
| Mechanism of action | The bactericidal action of temafloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited. |
| Absorption | Studies in healthy volunteers indicate that the average bioavailability of temafloxacin exceeds 90%, with little intersubject variability. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Hepatic. |
| Route of elimination | Not Available |
| Half life | Approximately 8 hours in patients with normal renal function. |
| Clearance | Not Available |
| Toxicity | Severe adverse reactions, including allergic reactions and hemolytic anemia, developed in about fifty patients during the first four months of its use, leading to three patient deaths |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | solid | ||||||||||||||||||||||||||||||||||||
| Melting point | Not Available | ||||||||||||||||||||||||||||||||||||
| Experimental Properties |
|
||||||||||||||||||||||||||||||||||||
| Predicted Properties |
|
||||||||||||||||||||||||||||||||||||
药物相互作用
| Drug | Interaction |
|---|---|
| Calcium | Formation of non-absorbable complexes |
| Iron Dextran | Formation of non-absorbable complexes |
| Magnesium | Formation of non-absorbable complexes |
食物相互作用
Not Available
收藏