药品详细
Idoxuridine (Idoxuridine )
化学结构式图
中文名
Idoxuridine
英文名
Idoxuridine
分子式
Not Available
化学名
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione
分子量
Average: 354.0985
Monoisotopic: 353.971264892
Monoisotopic: 353.971264892
CAS号
54-42-2
ATC分类
D06B 未知;J05A Direct acting antivirals;S01A 抗感染药
药物类型
small molecule
阶段
商品名
Antizona;Dendrid;Emanil;Heratil;Herpe-Gel;Herpes-Gel;Herpesil;Herpid;Herpidu;Herplex;Herplex Liquifilm;Idexur;Idoxene;Idu Oculos;Iducher;Idulea;Iduridin;Iduviran;Joddeoxiuridin;Kerecid;Ophthalmadine;Spectanefran;Stoxil;Synmiol;Virudox;
同义名
5IDU;5IUDR;Allergan 201;Allergan 211;ID2;Idossuridina [DCIT];Idoxuridin;Idoxuridina [INN-Spanish];Idoxuridinum [INN-Latin];IDU;IDUR;Iododeoxyridine;Iodoxuridine;IUDR;
基本介绍
An analog of deoxyuridine that inhibits viral DNA synthesis. The drug is used as an antiviral agent. [PubChem]
生产厂家
- Alcon laboratories inc
- Allergan pharmaceutical
- Glaxosmithkline
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference |
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剂型
| Form | Route | Strength |
|---|---|---|
| Liquid | Topical | |
| Solution / drops | Ophthalmic |
规格
| Unit description | Cost | Unit |
|---|---|---|
| Idoxuridine powder | 273.88 USD | g |
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
ANTIVIRALS 抗病毒;
药理
| Indication | For use in keratoconjunctivitis and keratitis caused by herpes simplex virus. |
| Pharmacodynamics | In chemical structure idoxuridine closely approximates the configuration of thymidine, one of the four building blocks of DNA (the genetic material of the Herpes virus). As a result, idoxuridine is able to replace thymidine in the enzymatic step of viral replication or "growth". The consequent production of faulty DNA results in a pseudostructure which cannot infect or destroy tissue. In short, by pre-empting a vital building block in the genetic material of the Herpes simplex virus, Herplex-D topical solution destroys the infective and destructive capacity of the viral material. The virus infected cell may only be attacked during the period of active synthesis of DNA. This occurs early in the development of the Herpes simplex lesion, but at different times in different cells. Therefore, ideally, the affected area should remain saturated with the antiviral agent. |
| Mechanism of action | Idoxuridine acts as an antiviral agent by inhibiting viral replication by substituting itself for thymidine in viral DNA. This in turn inhibits thymidylate phosphorylase and viral DNA polymerases from properly functioning. The effect of Idoxuridine results in the inability of the virus to reproduce or to infect/destroy tissue. |
| Absorption | Systemic absorption is unlikely following ocular administration even when nasolacrimal secretions are swallowed, since vidarabine is rapidly deaminated in the gastrointestinal tract. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Idoxuridine is rapidly inactivated by deaminases or nucleotidases. |
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Hypersensitivity or increased sensitivity of eyes to light. LD50=3080 mg/kg (orally in mice). |
| Affected organisms |
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| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | solid | ||||||||||||||||||||||||||||||||||||
| Melting point | 164-166 | ||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
Not Available
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