药品详细
Masoprocol (Masoprocol )
化学结构式图
中文名
Masoprocol
英文名
Masoprocol
分子式
Not Available
化学名
4-[(2S,3R)-3-[(3,4-dihydroxyphenyl)methyl]-2-methylbutyl]benzene-1,2-diol
分子量
Average: 302.3649
Monoisotopic: 302.151809192
Monoisotopic: 302.151809192
CAS号
500-38-9
ATC分类
L01X 其它抗肿瘤药
药物类型
small molecule
阶段
商品名
Actinex;
同义名
Dihydronorguaiaretic acid;Masoprocolum [INN-Latin];meso-NDGA;meso-Nordihydroguaiaretic acid;NDGA;Nordihydroguaiaretic acid;Nordihydroguairaretic acid;
基本介绍
A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils. [PubChem]
生产厂家
- Univ arizona cancer center
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
| Form | Route | Strength |
|---|---|---|
| Solution | Topical |
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
Cancer 癌症;
药理
| Indication | Used for the treatment of actinic keratoses (precancerous skin growths that can become malignant if left untreated). |
| Pharmacodynamics | Masoprocol is a novel antineoplastic agent. It is not known exactly how masoprocol works. Laboratory experiments have shown that masoprocol prevents cells similar to the ones found in actinic keratoses from multiplying. Masoprocol was withdrawn from the U.S. market in June 1996. |
| Mechanism of action | Although the exact mechanism of action is not known, studies have shown that masoprocol is a potent 5-lipoxygenase inhibitor and has antiproliferative activity against keratinocytes in tissue culture, but the relationship between this activity and its effectiveness in actinic keratoses is unknown. Masoprocol also inhibits prostaglandins but the significance of this action is not yet known. |
| Absorption | Less than 1%-2% is absorbed through the skin over a 4-day period following application. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism | |
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Symptoms of overdose or allergic reaction include bluish coloration of skin, dizziness, severe, or feeling faint, wheezing or trouble in breathing. |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | solid | ||||||||||||||||||||||||||||||||||||
| Melting point | 185.5 oC | ||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
Not Available
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