药品详细
Pipobroman(哌泊溴烷)
化学结构式图
中文名
哌泊溴烷
英文名
Pipobroman
分子式
C10H16Br2N2O2
化学名
3-bromo-1-[4-(3-bromopropanoyl)piperazin-1-yl]propan-1-one
分子量
Average: 356.054
Monoisotopic: 353.95785306
Monoisotopic: 353.95785306
CAS号
54-91-1
ATC分类
L01A 烷化剂
药物类型
small molecule
阶段
approved
商品名
Amedel;Vercyte;
同义名
基本介绍
An antineoplastic agent that acts by alkylation. [PubChem]
生产厂家
- Abbott laboratories pharmaceutical products div
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
|
| Substructures |
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适应症
Cancer 癌症;
药理
| Indication | For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia. |
| Pharmacodynamics | Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia. |
| Mechanism of action | The mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death. |
| Absorption | Well absorbed from the GI tract. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Not Available
|
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Symptoms of overdose include hematologic toxicity, especially with chronic overdosage. |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | ||||||||||||||||||||||||||||||||||||||||
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| State | solid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Acebutolol | Antagonism |
| Atenolol | Antagonism |
| Betaxolol | Antagonism |
| Bevantolol | Antagonism |
| Bisoprolol | Antagonism |
| Carteolol | Antagonism |
| Carvedilol | Antagonism |
| Esmolol | Antagonism |
| Labetalol | Antagonism |
| Metoprolol | Antagonism |
| Nadolol | Antagonism |
| Oxprenolol | Antagonism |
| Penbutolol | Antagonism |
| Pindolol | Antagonism |
| Practolol | Antagonism |
| Propranolol | Antagonism |
| Sotalol | Antagonism |
| Timolol | Antagonism |
食物相互作用
Not Available
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