药品详细
Alitretinoin(阿利维A酸)
化学结构式图
中文名
阿利维A酸
英文名
Alitretinoin
分子式
C20H28O2
化学名
(2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
分子量
Average: 300.4351
Monoisotopic: 300.20893014
Monoisotopic: 300.20893014
CAS号
5300-03-8
ATC分类
L01X 其它抗肿瘤药;D11A 未知
药物类型
small molecule
阶段
approved
商品名
Panretin;Panretin Gel;Panretyn;Panrexin;Renova;Retin-A;Retin-A Micro;Vesanoid;
同义名
alitretinoin;ALRT-1057;BAL4079;Retinoic Acid;
基本介绍
An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute). [PubChem]
生产厂家
- Eisai inc
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes | Not Available |
| Substructures | Not Available |
适应症
Cancer 癌症;
药理
| Indication | For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. |
| Pharmacodynamics | Alitretinoin (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. Alitretinoin inhibits the growth of Kaposi's sarcoma (KS) cells in vitro. |
| Mechanism of action | Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells. |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Not Available
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| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Not Available |
| Affected organisms |
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| Pathways | Not Available |
理化性质
| Properties | ||||||||||||||||||||||||||||||||||||||||
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| State | solid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
Not Available
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