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药品详细

Tenoxicam(替诺昔康)

化学结构式图
中文名
替诺昔康
英文名
Tenoxicam
分子式
C13H11N3O4S2
化学名
(3Z)-3-{hydroxy[(pyridin-2-yl)amino]methylidene}-2-methyl-2H,3H,4H-1$l^{6},5,2-thieno[2,3-e][1$l^{6},2]thiazine-1,1,4-trione
分子量
Average: 337.374
Monoisotopic: 337.019097235
CAS号
59804-37-4
ATC分类
M01A 未知
药物类型
small molecule
阶段
approved
商品名
Apo-Tenoxicam;Novo-Tenoxicam;Tilcotil;
同义名
Tenoxicamum [INN-Latin];
基本介绍

Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Pyridines and Derivatives
    • Aminopyridines and Derivatives
    Substructures
    • Hydroxy Compounds
    • Amino Ketones
    • Pyridines and Derivatives
    • Sulfonyls
    • Aminopyridines and Derivatives
    • Heterocyclic compounds
    • Aromatic compounds
    • Sulfonamides
    • Thiophenes
    • Ketones
    适应症
    ANTIINFLAMMATORY AND ANTIRHEUMATIC 消炎抗风湿;
    药理
    Indication For the treatment of rheumatoid arthritis, osteoarthritis, backache, and pain.
    Pharmacodynamics Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.
    Mechanism of action The antiinflammatory effects of tenoxicam may result from the inhibition of the enzyme cycooxygenase and the subsequent peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, their inhibition accounts for the peripheral analgesic effects of tenoxicam. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.
    Absorption Oral absorption of tenoxicam is rapid and complete (absolute bioavailability 100%).
    Volume of distribution Not Available
    Protein binding 99%
    Metabolism
    Tenoxicam is metabolized in the liver to several pharmacologically inactive metabolites (mainly 5'-hydroxy-tenoxicam).

    Important The metabolism module of DrugBank is currently in beta. Questions or suggestions? Please contact us.

    Substrate Enzymes Product
    Tenoxicam
    		5'-Hydroxylornoxicam Details
    Tenoxicam
    		5'-Hydroxytenoxicam Details
    Route of elimination Not Available
    Half life 72 hours (range 59 to 74 hours)
    Clearance Not Available
    Toxicity Not Available
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties
    Property Value Source
    melting point 211 dec °C PhysProp
    water solubility 14.1 mg/L Not Available
    logP 1.9 Not Available
    Predicted Properties
    Property Value Source
    water solubility 2.77e-01 g/l ALOGPS
    logP 1.82 ALOGPS
    logP 1.22 ChemAxon
    logS -3.1 ALOGPS
    pKa (strongest acidic) 7.21 ChemAxon
    pKa (strongest basic) 4.78 ChemAxon
    physiological charge 0 ChemAxon
    hydrogen acceptor count 6 ChemAxon
    hydrogen donor count 2 ChemAxon
    polar surface area 99.6 ChemAxon
    rotatable bond count 2 ChemAxon
    refractivity 93.06 ChemAxon
    polarizability 31.08 ChemAxon
    药物相互作用
    Drug Interaction
    Acenocoumarol The NSAID, tenoxicam, may increase the anticoagulant effect of acenocoumarol.
    Alendronate Increased risk of gastric toxicity
    Anisindione The NSAID, tenoxicam, may increase the anticoagulant effect of anisindione.
    Chlorthalidone Tenoxicam may antagonize the blood pressure lowering effect of Chlorthalidone. Monitor for changes in the therapeutic effect of Chlorthalidone if Tenoxicam is initiated, discontinued or dose changed.
    Cholestyramine Cholestyramine may decrease the serum concentration of Tenoxicam by increasing clearance. Monitor for changes in Tenoxicam therapeutic and adverse effects if Cholestyramine is initiated, discontinued or dose changed.
    Cyclosporine Monitor for nephrotoxicity
    Dicumarol The NSAID, tenoxicam, may increase the anticoagulant effect of dicumarol.
    Hydrochlorothiazide Tenoxicam may antagonize the blood pressure lowering effect of Hydrochlorothiazide. Monitor for changes in the therapeutic effect of Hydrochlorothiazide if Tenoxicam is initiated, discontinued or dose changed.
    Lithium Tenoxicam may increase the serum concentration of Lithium. A dose adjustment of Lithium may be required. Monitor for changes in Lithium therapeutic and adverse effects if Tenoxicam is initiated, discontinued or dose changed.
    Methotrexate Tenoxicam may increase the serum concentration of Methotrexate by reducing renal tubular secretion of Methotrexate. Monitor for changes in Methotrexate therapeutic and adverse effects if Tenoxicam is initiated, discontinued or dose changed.
    Metolazone Tenoxicam may antagonize the blood pressure lowering effect of Metolazone. Monitor for changes in the therapeutic effect of Metolazone if Tenoxicam is initiated, discontinued or dose changed.
    Warfarin The NSAID, tenoxicam, may increase the anticoagulant effect of warfarin.
    食物相互作用
    Not Available

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