药品详细
Fenoprofen (非诺洛芬 )
化学结构式图
中文名
非诺洛芬
英文名
Fenoprofen
分子式
Not Available
化学名
2-(3-phenoxyphenyl)propanoic acid
分子量
Average: 242.2699
Monoisotopic: 242.094294314
Monoisotopic: 242.094294314
CAS号
34597-40-5
ATC分类
M01A 未知
药物类型
small molecule
阶段
商品名
Nalfon;
同义名
Feneprofen calcium salt dihydrate;Fenoprofen calcium;Fenoprofen calcium hydrate;
基本介绍
An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding. [PubChem]
生产厂家
- Actavis elizabeth llc
- American therapeutics inc
- Clonmel healthcare ltd
- Dista products co div eli lilly and co
- Halsey drug co inc
- Ivax pharmaceuticals inc sub teva pharmaceuticals usa
- Mutual pharmaceutical co inc
- Mylan pharmaceuticals inc
- Par pharmaceutical inc
- Pedinol pharmacal inc
- Quantum pharmics ltd
- Sandoz inc
- Usl pharma inc
- Warner chilcott div warner lambert co
- Watson laboratories inc
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
| Form | Route | Strength |
|---|---|---|
| Capsule | Oral |
规格
| Unit description | Cost | Unit |
|---|---|---|
| Fenoprofen calcium powder | 1.59 USD | g |
| Fenoprofen Calcium 600 mg tablet | 1.01 USD | tablet |
| Nalfon 200 mg capsule | 0.91 USD | capsule |
| Fenoprofen 600 mg tablet | 0.88 USD | tablet |
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
ANTIINFLAMMATORY AND ANTIRHEUMATIC 消炎抗风湿;
药理
| Indication | For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Also for the relief of mild to moderate pain. |
| Pharmacodynamics | Fenoprofen is a propionic acid derivative with analgesic, antiinflammatory and antipyretic properties. Fenoprofen inhibits prostaglandin synthesis by decreasing the enzyme needed for biosynthesis. In patients with rheumatoid arthritis, the anti-inflammatory action of fenoprofen has been evidenced by relief of pain, increase in grip strength, and reductions in joint swelling, duration of morning stiffness, and disease activity (as assessed by both the investigator and the patient). In patients with osteoarthritis, the anti-inflammatory and analgesic effects of fenoprofen have been demonstrated by reduction in tenderness as a response to pressure and reductions in night pain, stiffness, swelling, and overall disease activity (as assessed by both the patient and the investigator). These effects have also been demonstrated by relief of pain with motion and at rest and increased range of motion in involved joints. In patients with rheumatoid arthritis and osteoarthritis, clinical studies have shown fenoprofen to be comparable to aspirin in controlling the aforementioned measures of disease activity, but mild gastrointestinal reactions (nausea, dyspepsia) and tinnitus occurred less frequently in patients treated with fenoprofen than in aspirin-treated patients. It is not known whether fenoprofen causes less peptic ulceration than does aspirin. In patients with pain, the analgesic action of fenoprofen has produced a reduction in pain intensity, an increase in pain relief, improvement in total analgesia scores, and a sustained analgesic effect. |
| Mechanism of action | Fenoprofen's exact mode of action is unknown, but it is thought that prostaglandin synthetase inhibition is involved. Fenoprofen has been shown to inhibit prostaglandin synthetase isolated from bovine seminal vesicles. |
| Absorption | Rapidly absorbed under fasting conditions, and peak plasma levels of 50 µg/mL are achieved within 2 hours after oral administration of 600 mg doses. |
| Volume of distribution | Not Available |
| Protein binding | 99% to albumin. |
| Metabolism |
About 90% of a single oral dose is eliminated within 24 hours as fenoprofen glucuronide and 4'-hydroxyfenoprofen glucuronide, the major urinary metabolites of fenoprofen. |
| Route of elimination | Not Available |
| Half life | Plasma half-life is approximately 3 hours. |
| Clearance | Not Available |
| Toxicity | Symptoms of overdose appear within several hours and generally involve the gastrointestinal and central nervous systems. They include dyspepsia, nausea, vomiting, abdominal pain, dizziness, headache, ataxia, tinnitus, tremor, drowsiness, and confusion. Hyperpyrexia, tachycardia, hypotension, and acute renal failure may occur rarely following overdose. Respiratory depression and metabolic acidosis have also been reported following overdose with certain NSAIDs. |
| Affected organisms |
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| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | solid | ||||||||||||||||||||||||||||||||||||
| Melting point | Not Available | ||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Acenocoumarol | The NSAID, fenoprofen, may increase the anticoagulant effect of acenocoumarol. |
| Alendronate | Increased risk of gastric toxicity |
| Anisindione | The NSAID, fenoprofen, may increase the anticoagulant effect of anisindione. |
| Cyclosporine | Monitor for nephrotoxicity |
| Dicumarol | The NSAID, fenoprofen, may increase the anticoagulant effect of dicumarol. |
| Ginkgo biloba | Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided. |
| Methotrexate | The NSAID, fenoprofen, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity. |
| Telmisartan | Concomitant use of Telmisartan and Fenoprofen may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment. |
| Timolol | The NSAID, Fenoprofen, may antagonize the antihypertensive effect of Timolol. |
| Trandolapril | The NSAID, Fenoprofen, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Fenoprofen is initiated, discontinued or dose changed. |
| Treprostinil | The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Fenoprofen. Monitor for increased bleeding during concomitant thearpy. |
| Warfarin | The antiplatelet effects of fenoprofen may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy. |
食物相互作用
- Avoid alcohol.
- Take with food to reduce irritation.
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