药品详细
Dextrothyroxine (Dextrothyroxine )
化学结构式图
中文名
Dextrothyroxine
英文名
Dextrothyroxine
分子式
Not Available
化学名
2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
分子量
Average: 776.87
Monoisotopic: 776.686681525
Monoisotopic: 776.686681525
CAS号
51-49-0
ATC分类
C10A 未知;H03A 未知
药物类型
small molecule
阶段
商品名
Choloxin (Knoll (Canada) (discontinued), Baxter (United Kingdom) (discontinued), Boots-Flint (United States) (discontinued));Dynothel (Henning (Germany) (discontinued));Eulipos (Boehringer Mannheim (Germany) (discontinued));Lisolipin (Bracco (Italy) (discontinued));
同义名
3,5,3′,5′-Tetraiodo-d-thyronine Sodium;D-Thyroxine Sodium;Dekstrotyroksiininatrium;Dextrothyroxinum Natricum;Dextrotiroxina sódica;Dextrotyroxinnatrium;Sodium 4-O-(4-hydroxy-3,5-di-iodophenyl)-3,5-di-iodo-d-tyrosinate hydrate;
基本介绍
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism. [PubChem]
生产厂家
- Abbott laboratories pharmaceutical products div
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
| Form | Route | Strength |
|---|---|---|
| Powder, for solution | Intravenous | |
| Tablet | Oral |
规格
化合物类型
| Type | small molecule |
| Classes |
|
| Substructures |
|
适应症
hyperlipidemi 高血脂;
药理
| Indication | Used to lower high cholesterol levels in the blood. |
| Pharmacodynamics | Dextrothyroxine, the dextrorotary isomer of the synthetic thyroxine, is a antihyperlipidemic. |
| Mechanism of action | Dextrothyroxine is a antihyperlipidemic. The mechanism of action is not completely understood, but dextrothyroxine apparently acts in the liver to stimulate formation of low-density lipoprotein (LDL) and, to a much greater extent, to increase catabolism of LDL. This leads to increased excretion of cholesterol and bile acids via the biliary route into the feces, with a resulting reduction in serum cholesterol and LDL. Dextrothyroxine has no significant effect on high-density lipoproteins (HDL). Inherently, it will also bind to thyroid receptors and as it is a prohormone, it will bind as a substrate to iodide peroxidase. |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism | |
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Symptoms of dextrothyroxine overdose are unknown. |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | solid | ||||||||||||||||||||||||||||||||||||
| Melting point | 235 - 236 oC | ||||||||||||||||||||||||||||||||||||
| Experimental Properties |
|
||||||||||||||||||||||||||||||||||||
| Predicted Properties |
|
||||||||||||||||||||||||||||||||||||
药物相互作用
| Drug | Interaction |
|---|---|
| Acenocoumarol | The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of acenocoumarol. |
| Anisindione | The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of anisindione. |
| Dicumarol | The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of dicumarol. |
| Digoxin | The thyroid hormone, dextrothyroxine, decreases the effect of digoxin. |
| Warfarin | The thyroid hormone, dextrothyroxine, increase the anticoagulant effect of warfarin. |
食物相互作用
- Take without regard to meals.
收藏