药品详细
Phenoxybenzamine(酚苄明)
化学结构式图
中文名
酚苄明
英文名
Phenoxybenzamine
分子式
C18H22ClNO
化学名
benzyl(2-chloroethyl)(1-phenoxypropan-2-yl)amine
分子量
Average: 303.826
Monoisotopic: 303.138992038
Monoisotopic: 303.138992038
CAS号
59-96-1
ATC分类
C04A 未知
药物类型
small molecule
阶段
approved
商品名
Bensylyt;Bensylyt Nen;Bensylyte;Benzylyt;Dibenylin;Dibenyline;Dibenzylene;Dibenzyline;Dibenzyline Hydrochloride;Dibenzyran;
同义名
Fenossibenzamina [Dcit];Fenoxibenzamina [INN-Spanish];Phenoxybenzamine Hcl;Phenoxybenzamine Hydrochloride;Phenoxybenzaminum [INN-Latin];POB HCl;
基本介绍
An alpha-adrenergic antagonist with long duration of action. It has been used to treat hypertension and as a peripheral vasodilator. [PubChem]
生产厂家
- Wellspring pharmaceutical corp
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference |
|
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
|
| Substructures |
|
适应症
ANTIHYPERTENSIVES 降血压;
药理
| Indication | For the treatment of phaeochromocytoma (malignant), benign prostatic hypertrophy and malignant essential hypertension. |
| Pharmacodynamics | Phenoxybenzamine is indicated for the control of episodes of hypertension and sweating that occur with a disease called pheochromocytoma. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly. Phenoxybenzamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain "chemical sympathectomy" by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system. Phenoxybenzamine works by blocking alpha receptors in certain parts of the body. Alpha receptors are present in the muscle that lines the walls of blood vessels. When the receptors are blocked by Phenoxybenzamine, the muscle relaxes and the blood vessels widen. This widening of the blood vessels results in a lowering of blood pressure. |
| Mechanism of action | Phenoxybenzamine produces its therapeutic actions by blocking alpha receptors, leading to a muscle relaxation and a widening of the blood vessels. This widening of the blood vessels results in a lowering of blood pressure. |
| Absorption | Twenty to 30 percent of orally administered phenoxybenzamine appears to be absorbed in the active form. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Not Available
|
| Route of elimination | Not Available |
| Half life | 24 hours |
| Clearance | Not Available |
| Toxicity | Symptoms of overdose are largely the result of block of the sympathetic nervous system and of the circulating epinephrine. They may include postural hypotension resulting in dizziness or fainting, tachycardia, particularly postural, vomiting; lethargy, and shock. |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | ||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| State | solid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
|
|||||||||||||||||||||||||||||||||||||||
| Predicted Properties |
|
|||||||||||||||||||||||||||||||||||||||
药物相互作用
| Drug | Interaction |
|---|---|
| Tadalafil | Tadalafil may enhance the hypotensive effect of Phenoxybenzamine. Monitor for hypotension during concomitant therapy. |
| Tamsulosin | Concomitant use of alpha1-adrenergic antagonists, Tamsulosin and Phenoxybenzamine, may result in additive antihypertensive effects. Combination therapy is not recommended. |
| Treprostinil | Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use. |
| Vardenafil | Additive hypotensive effects of the PDE5 inhibitor, Vardenafil, and alpha1-blocker, Phenoxybenzamine, may occur. Monitor for hypotension during concomitant therapy. |
食物相互作用
Not Available
收藏