Acigena;Almederm;AT-7;Bilevon;Bivelon;Compound G-11;Cotofilm;Dermadex;Dial;Distodin;E-Z Scrub;Eleven;Exofene;Fascol;Fesia-Sin;Fomac;Fostril;G-Eleven;G-II;Gamophen;Gamophene;Germa-Medica;HCP;Hexa-Germ;Hexabalm;Hexachlorofen;Hexachlorophane;Hexachlorophen;Hexachlorophene, Pharma;Hexafen;Hexascrub;Hexazinone;Hexide;Hexophene;Hexosan;Isobac;Isobac 20;Nabac;Nabac 25 Ec;Neosept V;Phiso-Scrub;Phisodan;Phisohex;Pre-Op;Rcra Waste Number U132;Ritosept;Scrubteam Surgical Spongebrush;Septi-Soft;Septisol;Septofen;Soy-Dome;Ster-Zac;Steral;Steraskin;Surgi-Cen;Surgi-Cin;Surofene;Tersaseptic;Trichlorophene;Turgex;

A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)

• 3m co
• Arbrook inc
• Bayer pharmaceuticals corp
• Becton dickinson and co
• Calgon corp div merck and co inc
• Davis and geck div american cyanamid co
• Dial corp div greyhound co
• Huntington laboratories inc
• Professional disposables inc
• Sanofi aventis us llc
• Vestal laboratories div chemed corp
• Xttrium laboratories inc

• Bayer Healthcare
• Doak Dermatologics
• Physicians Total Care Inc.
• Sanofi-Aventis Inc.
• Spectrum Pharmaceuticals

Synthesis Reference	Not Available
General Reference	Not Available

Form	Route	Strength
Emulsion	Topical

Unit description	Cost	Unit
Phisohex 148ml Bottle	35.46 USD	bottle
Hexachlorophene powder	11.47 USD	g
Phisohex 3% cleanser	0.18 USD	ml
Phisohex 473ml Bottle	0.13 USD	ml
Tersaseptic cleanser	0.05 USD	g

Type	small molecule

Classes

Diphenylmethanes

Substructures

Hydroxy Compounds Phenols and Derivatives Benzene and Derivatives Aryl Halides Halobenzenes Diphenylmethanes Aromatic compounds Phenyl Esters

Indication	For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.
Pharmacodynamics	Hexachlorophene, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue.
Mechanism of action	The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.
Absorption	Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.
Volume of distribution	Not Available
Protein binding	92%
Metabolism
Route of elimination	Not Available
Half life	Not Available
Clearance	Not Available
Toxicity	Oral, rat LD50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.
Affected organisms	Enteric bacteria and other eubacteria
Pathways	Not Available

Properties
State	liquid
Melting point	166.5 oC (boiling point)
Experimental Properties	Property Value Source water solubility 140 mg/L PhysProp logP 6.3 PhysProp pKa 4.95 Various sources
Predicted Properties	Property Value Source water solubility 4.33e-04 g/l ALOGPS logP 6.77 ALOGPS logP 7.08 ChemAxon Molconvert logS -5.97 ALOGPS pKa 8.79 ChemAxon Molconvert hydrogen acceptor count 2 ChemAxon Molconvert hydrogen donor count 2 ChemAxon Molconvert polar surface area 40.46 ChemAxon Molconvert rotatable bond count 2 ChemAxon Molconvert refractivity 88.59 ChemAxon Molconvert polarizability 34.07 ChemAxon Molconvert

Drug	Interaction

Not Available