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药品详细

Aceprometazine(醋异丙嗪)

化学结构式图
中文名
醋异丙嗪
英文名
Aceprometazine
分子式
C19H22N2OS
化学名
1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethan-1-one
分子量
Average: 326.456
Monoisotopic: 326.145284026
CAS号
13461-01-3
ATC分类
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Aceprometazine (INN) is a prescription drug with neuroleptic and anti-histamine properties. It is not widely prescribed. It may be used in combination with meprobamate for the treatment of sleep disorders. This combination is available in France under the trade name Mepronizine. [Wikipedia]

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Phenothiazines
    Substructures
    • Ethers
    • Phenothiazines
    • Aliphatic and Aryl Amines
    • Thiazines
    • Benzene and Derivatives
    • Heterocyclic compounds
    • Aromatic compounds
    • Benzoyl Derivatives
    • Anilines
    • Ketones
    适应症
    药理
    Indication Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders.
    Pharmacodynamics Aceprometazine is a drug with neuroleptic and anti-histamine properties. It is not widely prescribed.
    Mechanism of action Aceprometazine, acting as an H1-receptor antagonist can induce sedation by being able to cross the blood-brain-barrier and binding to H1-receptors in the central nervous system.
    Absorption Rapidly absorbed following oral administration.
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Hepatic.
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Not Available
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties Not Available
    Predicted Properties
    Property Value Source
    water solubility 1.22e-02 g/l ALOGPS
    logP 4.35 ALOGPS
    logP 3.85 ChemAxon
    logS -4.4 ALOGPS
    pKa (strongest acidic) 16.06 ChemAxon
    pKa (strongest basic) 8.32 ChemAxon
    physiological charge 1 ChemAxon
    hydrogen acceptor count 3 ChemAxon
    hydrogen donor count 0 ChemAxon
    polar surface area 23.55 ChemAxon
    rotatable bond count 4 ChemAxon
    refractivity 98.91 ChemAxon
    polarizability 36.79 ChemAxon
    药物相互作用
    Drug Interaction
    Donepezil Possible antagonism of action
    Galantamine Possible antagonism of action
    食物相互作用
    Not Available

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