药品详细
Acetohydroxamic Acid(乙酰氧肟酸)
化学结构式图
中文名
乙酰氧肟酸
英文名
Acetohydroxamic Acid
分子式
C2H5NO2
化学名
N-hydroxyacetamide
分子量
Average: 75.0666
Monoisotopic: 75.032028409
Monoisotopic: 75.032028409
CAS号
546-88-3
ATC分类
G04B 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
生产厂家
- Mission pharmacal co
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections. |
| Pharmacodynamics | Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. |
| Mechanism of action | Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting organisms, leading to a decrease in pH and ammonia levels. As antimicrobial agents are more effective in such conditions, the effectiveness of these agents is amplified, resulting in a higher cure rate. |
| Absorption | Well absorbed from the GI tract following oral administration. |
| Volume of distribution | Not Available |
| Protein binding | No known binding |
| Metabolism |
35-65% of oral dose excreted unchanged in urine (which provides the drug's therapeutic effect).
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| Route of elimination | Not Available |
| Half life | 5-10 hours in patients with normal renal function |
| Clearance | Not Available |
| Toxicity | Oral, rat: LD50 = 4.8gm/kg. Symptoms of overdose include anorexia, malaise, lethargy, diminished sense of wellbeing, tremor, anxiety, nausea, and vomiting. |
| Affected organisms |
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| Pathways | Not Available |
理化性质
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
Not Available
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