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药品详细

Adenine(腺嘌呤)

化学结构式图
中文名
腺嘌呤
英文名
Adenine
分子式
C5H5N5
化学名
7H-purin-6-amine
分子量
Average: 135.1267
Monoisotopic: 135.054495185
CAS号
73-24-5
ATC分类
药物类型
small molecule
阶段
approved, nutraceutical
商品名
同义名
基本介绍

A purine base and a fundamental unit of adenine nucleotides. [PubChem]

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Purines and Purine Derivatives
    Substructures
    • Aliphatic and Aryl Amines
    • Pyrimidines and Derivatives
    • Imidazoles
    • Heterocyclic compounds
    • Aromatic compounds
    • Purines and Purine Derivatives
    • Cyanamides
    适应症
    药理
    Indication For nutritional supplementation, also for treating dietary shortage or imbalance
    Pharmacodynamics Adenine (sometimes known as vitamin B4) combines with the sugar ribose to form adenosine, which in turn can be bonded with from one to three phosphoric acid units, yielding AMP, ADP and ATP . These adenine derivatives perform important functions in cellular metabolism. Adenine is one of four nitrogenous bases utilized in the synthesis of nucleic acids. A modified form of adenosine monophosphate (cyclic AMP) is an imporant secondary messenger in the propagation of many hormonal stimuli. Adenine is an integral part of the structure of many coenzymes. Adenosine (adenine with a ribose group) causes transient heart block in the AV node of the heart. In individuals suspected of suffering from a supraventricular tachycardia (SVT), adenosine is used to help identify the rhythm. Certain SVTs can be successfully terminated with adenosine.
    Mechanism of action Adenine forms adenosine, a nucleoside, when attached to ribose, and deoxyadenosine when attached to deoxyribose, and it forms adenosine triphosphate (ATP), a nucleotide, when three phosphate groups are added to adenosine. Adenosine triphosphate is used in cellular metabolism as one of the basic methods of transferring chemical energy between reactions. In older literature, adenine was sometimes called Vitamin B4Not Available
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Not Available
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties
    Property Value Source
    melting point 360 dec °C PhysProp
    water solubility 1030 mg/L (at 25 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992)
    logP -0.09 HANSCH,C ET AL. (1995)
    logS -2.12 ADME Research, USCD
    pKa 4.15 (at 25 °C) KORTUM,G ET AL (1961)
    Predicted Properties
    Property Value Source
    water solubility 1.15e+01 g/l ALOGPS
    logP -0.38 ALOGPS
    logP -0.57 ChemAxon
    logS -1.1 ALOGPS
    pKa (strongest acidic) 10.29 ChemAxon
    pKa (strongest basic) 5.32 ChemAxon
    physiological charge 0 ChemAxon
    hydrogen acceptor count 4 ChemAxon
    hydrogen donor count 2 ChemAxon
    polar surface area 80.48 ChemAxon
    rotatable bond count 0 ChemAxon
    refractivity 38.22 ChemAxon
    polarizability 12.29 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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