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药品详细

Almitrine(阿米三嗪)

化学结构式图
中文名
阿米三嗪
英文名
Almitrine
分子式
C26H29F2N7
化学名
6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-N,4-N-bis(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine
分子量
Average: 477.5522
Monoisotopic: 477.245250373
CAS号
27469-53-0
ATC分类
R07A Other Respiratory System Products
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep. [PubChem]

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Diphenylmethanes
    Substructures
    • Alkanes and Alkenes
    • Aliphatic and Aryl Amines
    • Piperazines
    • Benzene and Derivatives
    • Diphenylmethanes
    • Halobenzenes
    • Heterocyclic compounds
    • Aromatic compounds
    • Triazines
    • Cyanamides
    • Aryl Halides
    适应症
    药理
    Indication For the treatment of chronic obstructive pulmonary disease.
    Pharmacodynamics Almitrine is a respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.
    Mechanism of action Almitrine enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Not Available
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties Not Available
    Predicted Properties
    Property Value Source
    water solubility 1.44e-02 g/l ALOGPS
    logP 4.9 ALOGPS
    logP 6.05 ChemAxon
    logS -4.5 ALOGPS
    pKa (strongest acidic) 14.27 ChemAxon
    pKa (strongest basic) 7.49 ChemAxon
    physiological charge 1 ChemAxon
    hydrogen acceptor count 7 ChemAxon
    hydrogen donor count 2 ChemAxon
    polar surface area 69.21 ChemAxon
    rotatable bond count 10 ChemAxon
    refractivity 140.88 ChemAxon
    polarizability 51.12 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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