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药品详细

Amrinone(氨力农)

化学结构式图
中文名
氨力农
英文名
Amrinone
分子式
C10H9N3O
化学名
3-amino-5-(pyridin-4-yl)-1,2-dihydropyridin-2-one
分子量
Average: 187.198
Monoisotopic: 187.074561925
CAS号
60719-84-8
ATC分类
C01C 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Amrinone (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure.

生产厂家
  • Baxter healthcare corp anesthesia critical care
  • Bedford laboratories div ben venue laboratories inc
  • Hospira inc
  • Sanofi aventis us llc
封装厂家
参考
Synthesis Reference Not Available
General Reference Not Available
剂型
规格
化合物类型
Type small molecule
Classes
  • Pyridines and Derivatives
  • Aminopyridines and Derivatives
  • Pyridines
Substructures
  • Pyridines and Derivatives
  • Aliphatic and Aryl Amines
  • Aminopyridines and Derivatives
  • Pyridines
  • Heterocyclic compounds
  • Aromatic compounds
适应症
药理
Indication Used in the treatment of congestive heart failure.
Pharmacodynamics Amrinone is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
Mechanism of action Amrinone is a phosphodiesterase inhibitor (PDE3), resulting in increased cAMP and cGMP which leads to an increase in the calcium influx like that caused by beta-agonists resulting in increased inotropic effect.
Absorption Not Available
Volume of distribution
  • 1.2 L/kg [normal volunteers]
Protein binding 10 to 49%
Metabolism
Hepatic.
Route of elimination The primary route of excretion in man is via the urine as both inamrinone and several metabolites (N-glycolyl, N-acetate, O-glucuronide and N-glucuronide).
Half life 5 to 8 hours
Clearance Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Pathways Not Available
理化性质
Properties
State solid
Experimental Properties
Property Value Source
melting point 295 dec °C PhysProp
Predicted Properties
Property Value Source
water solubility 5.60e+00 g/l ALOGPS
logP 0.27 ALOGPS
logP -0.57 ChemAxon
logS -1.5 ALOGPS
pKa (strongest acidic) 11.01 ChemAxon
pKa (strongest basic) 4.87 ChemAxon
physiological charge 0 ChemAxon
hydrogen acceptor count 3 ChemAxon
hydrogen donor count 2 ChemAxon
polar surface area 68.01 ChemAxon
rotatable bond count 1 ChemAxon
refractivity 53.89 ChemAxon
polarizability 18.94 ChemAxon
药物相互作用
食物相互作用
Not Available

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