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药品详细

Antazoline(安他唑啉)

化学结构式图
中文名
安他唑啉
英文名
Antazoline
分子式
C17H19N3
化学名
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
分子量
Average: 265.3529
Monoisotopic: 265.157897623
CAS号
91-75-8
ATC分类
R01A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Antazoline is a 1st generation antihistamine that also anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.

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    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference
    1. Figus M, Fogagnolo P, Lazzeri S, Capizzi F, Romagnoli M, Canovetti A, Iester M, Ferreras A, Rossetti L, Nardi M: Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study. Eur J Ophthalmol. 2010 Sep-Oct;20(5):811-8. Pubmed
    剂型
    规格
    化合物类型
    Type small molecule
    Classes Not Available
    Substructures Not Available
    适应症
    药理
    Indication Used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.
    Pharmacodynamics Antazoline is a histamine H1 receptor antagonist. It selectively bind to but does not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
    Mechanism of action Antazoline binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Not Available
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties
    Property Value Source
    melting point 120 °C PhysProp
    water solubility 663 mg/L (at 30 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992)
    Predicted Properties
    Property Value Source
    water solubility 1.14e-01 g/l ALOGPS
    logP 3.22 ALOGPS
    logP 2.88 ChemAxon
    logS -3.4 ALOGPS
    pKa (strongest basic) 9.24 ChemAxon
    physiological charge 1 ChemAxon
    hydrogen acceptor count 3 ChemAxon
    hydrogen donor count 1 ChemAxon
    polar surface area 27.63 ChemAxon
    rotatable bond count 5 ChemAxon
    refractivity 82.89 ChemAxon
    polarizability 30.11 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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