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药品详细

Antipyrine(安替比林)

化学结构式图
中文名
安替比林
英文名
Antipyrine
分子式
C11H12N2O
化学名
1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one
分子量
Average: 188.2258
Monoisotopic: 188.094963016
CAS号
60-80-0
ATC分类
N02B Other Analgesics and Antipyretics;S02D 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Pyrazolones
    • Benzene and Derivatives
    • Anilines
    Substructures
    • Pyrazolones
    • Pyrazoles
    • Carboxylic Acids and Derivatives
    • Benzene and Derivatives
    • Heterocyclic compounds
    • Aromatic compounds
    • Imines
    • Anilines
    适应症
    药理
    Indication Antipyrine is an analgesic often used to test effects of other drugs on liver enzymes..
    Pharmacodynamics Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
    Mechanism of action Antipyrine is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available

    Important The metabolism module of DrugBank is currently in beta. Questions or suggestions? Please contact us.

    Substrate Enzymes Product
    Antipyrine
    		Norantipyrine Details
    Antipyrine
    		3-Hydroxymethylantipyrine Details
    Antipyrine
    		4-Hydroxyantipyrine Details
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Not Available
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties
    Property Value Source
    melting point 114 °C PhysProp
    boiling point 319 °C PhysProp
    water solubility 5.19E+004 mg/L (at 25 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992)
    logP 0.38 HANSCH,C ET AL. (1995)
    Caco2 permeability -4.55 ADME Research, USCD
    pKa 1.4 SANGSTER (1994)
    Predicted Properties
    Property Value Source
    water solubility 4.74e+01 g/l ALOGPS
    logP 1.18 ALOGPS
    logP 1.22 ChemAxon
    logS -0.6 ALOGPS
    pKa (strongest basic) 0.37 ChemAxon
    physiological charge 0 ChemAxon
    hydrogen acceptor count 2 ChemAxon
    hydrogen donor count 0 ChemAxon
    polar surface area 23.55 ChemAxon
    rotatable bond count 1 ChemAxon
    refractivity 56.42 ChemAxon
    polarizability 20.4 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

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