药品详细
Arbutamine(阿布他明)
化学结构式图
中文名
阿布他明
英文名
Arbutamine
分子式
C18H23NO4
化学名
4-[(1R)-1-hydroxy-2-{[4-(4-hydroxyphenyl)butyl]amino}ethyl]benzene-1,2-diol
分子量
Average: 317.3795
Monoisotopic: 317.162708229
Monoisotopic: 317.162708229
CAS号
128470-16-6
ATC分类
C01C 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Arbutamine, administered through a closed-loop, computer-controlled drug-delivery system, is indicated to elicit acute cardiovascular responses, similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease in patients who cannot exercise adequately .
生产厂家
- Gensia automedics inc
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | Used to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in patients who cannot exercise adequately. | ||||||||||||
| Pharmacodynamics | Not Available | ||||||||||||
| Mechanism of action | Arbutamine is a synthetic catecholamine with positive chronotropic and inotropic properties. The chronotropic (increase in heart rate) and inotropic (increase in force of contraction) effects of arbutamine serve to mimic exercise by increasing cardiac work (producing stress) and provoke myocardial ischemia in patients with compromised coronary arteries. The increase in heart rate caused by arbutamine is thought to limit regional subendocardial perfusion, thereby limiting tissue oxygenation. In functional assays, arbutamine is more selective for beta-adrenergic receptors than for alpha-adrenergic receptors. The beta-agonist activity of arbutamine provides cardiac stress by increasing heart rate, cardiac contractility, and systolic blood pressure. The degree of hypotension that occurs for a given chronotropic activity is less with arbutamine than, for example, with isoproterenol because alpha receptor activity is retained. | ||||||||||||
| Absorption | Not Available | ||||||||||||
| Volume of distribution | Not Available | ||||||||||||
| Protein binding | 58% | ||||||||||||
| Metabolism |
Primarily metabolized to methoxyarbutamine. Another possible metabolite is ketoarbutamine. The metabolites of arbutamine appear to have less pharmacological activity and a longer half-life and than the parental drug.
Important The metabolism module of DrugBank is currently in beta. Questions or suggestions? Please contact us.
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| Route of elimination | Not Available | ||||||||||||
| Half life | Elimination half-life is approximately 8 minutes. | ||||||||||||
| Clearance | Not Available | ||||||||||||
| Toxicity | Not Available | ||||||||||||
| Affected organisms |
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| Pathways | Not Available | ||||||||||||
理化性质
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| State | solid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
Not Available
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