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药品详细

Attapulgite(凹凸棒石)

化学结构式图
中文名
凹凸棒石
英文名
Attapulgite
分子式
Not Available
化学名
分子量
Not Available
CAS号
12174-11-7
ATC分类
A07B 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Attapulgite is a magnesium aluminium phyllosilicate which occurs in a type of clay soil common to the Southeastern United States. When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Until 2003, it was the active ingredient used in Kaopectate, before that product was reformulated with bismuth subsalicylate.

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    参考
    Synthesis Reference Not Available
    General Reference
    1. Zaid MR, Hasan M, Khan AA: Attapulgite in the treatment of acute diarrhoea: a double-blind placebo-controlled study. J Diarrhoeal Dis Res. 1995 Mar;13(1):44-6. Pubmed
    2. Nwachukwu CE, Okebe JU: Antimotility agents for chronic diarrhoea in people with HIV/AIDS. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD005644. Pubmed
    剂型
    规格
    化合物类型
    Type small molecule
    Classes Not Available
    Substructures Not Available
    适应症
    药理
    Indication When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Attapulgite is an adsorbent.
    Pharmacodynamics Attapulgite is an adsorptive magnesium aluminium phyllosilicate which binds to toxins, bacteria and water.
    Mechanism of action Attapulgite adsorbs water, toxins and bacteria, contributing to firmer stools, reducing fluid loss from diarrhea.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity Not Available
    Affected organisms Not Available
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties Not Available
    Predicted Properties Not Available
    药物相互作用
    Drug Interaction
    Chloroquine The antiacid decreases the absorption of chloroquine
    Clindamycin The aluminium salt decreases the absorption of lincosamides
    Demeclocycline Formation of non-absorbable complexes
    Doxycycline Formation of non-absorbable complexes
    Lincomycin The aluminium salt decreases the absorption of lincosamides
    Minocycline Formation of non-absorbable complexes
    Penciclovir The multivalent agent decreases the effect of penicillamine
    Tetracycline Formation of non-absorbable complexes
    食物相互作用
    Not Available

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