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药品详细

Bacampicillin(巴氨西林)

化学结构式图
中文名
巴氨西林
英文名
Bacampicillin
分子式
C21H27N3O7S
化学名
1-[(ethoxycarbonyl)oxy]ethyl (2S,5R,6R)-6-[(2R)-2-amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
分子量
Average: 465.52
Monoisotopic: 465.156970923
CAS号
50972-17-3
ATC分类
J01C Beta-lactam Antibacterials, Penicillins
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides. It is used to cure infection of upper and lower respiratory tract; skin and soft tissue; urinary tract and acute uncomplicated gonococcal urethritis etc.

生产厂家
  • Pfizer laboratories div pfizer inc
封装厂家
  • Pfizer Inc.
  • Pharmaceutical Utilization Management Program VA Inc.
参考
Synthesis Reference Not Available
General Reference Not Available
剂型
规格
化合物类型
Type small molecule
Classes
  • Penicillins
  • Phenethylamines
Substructures
  • Carboxylic Acids and Derivatives
  • Acetates
  • Amino Ketones
  • Aliphatic and Aryl Amines
  • Ethers
  • Benzene and Derivatives
  • Beta Lactams
  • Penicillins
  • Thiazoles
  • Phenethylamines
  • Heterocyclic compounds
  • Aromatic compounds
  • Carboxamides and Derivatives
  • Lactams
  • Azetidines
  • Carbonic Acids and Derivatives
  • Thiazolidines
适应症
药理
Indication For infections at the following sites: upper and lower respiratory tract; skin and soft tissue; urinary tract and acute uncomplicated gonococcal urethritis, when due to sensitive strains of the following organisms: Gram-positive: streptococci (including S. faecalis and S. pneumoniae) and nonpenicillinase-producing staphylococci; Gram-negative: H. influenzae, N. gonorrhoeae, E. coli, P. mirabilis, Salmonellae and Shigellae.
Pharmacodynamics Bacampicillin is a prodrug of ampicillin and is microbiologically inactive.
Mechanism of action During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal action through the inhibition of the biosynthesis of cell wall mucopeptides.
Absorption Absorbed following oral administration.
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Not Available
Affected organisms
  • Enteric bacteria and other eubacteria
Pathways Not Available
理化性质
Properties
State solid
Experimental Properties Not Available
Predicted Properties
Property Value Source
water solubility 1.23e-01 g/l ALOGPS
logP 1.17 ALOGPS
logP 1.47 ChemAxon
logS -3.6 ALOGPS
pKa (strongest acidic) 11.72 ChemAxon
pKa (strongest basic) 7.44 ChemAxon
physiological charge 1 ChemAxon
hydrogen acceptor count 6 ChemAxon
hydrogen donor count 2 ChemAxon
polar surface area 137.26 ChemAxon
rotatable bond count 10 ChemAxon
refractivity 113.76 ChemAxon
polarizability 46.8 ChemAxon
药物相互作用
Drug Interaction
Demeclocycline Possible antagonism of action
Doxycycline Possible antagonism of action
Ethinyl Estradiol This anti-infectious agent could decrease the effect of the oral contraceptive
Methotrexate The penicillin increases the effect and toxicity of methotrexate
Minocycline Possible antagonism of action
Tetracycline Possible antagonism of action
食物相互作用
Not Available

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