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药品详细

Bambuterol(班布特罗)

化学结构式图
中文名
班布特罗
英文名
Bambuterol
分子式
C18H29N3O5
化学名
3-[2-(tert-butylamino)-1-hydroxyethyl]-5-[(dimethylcarbamoyl)oxy]phenyl N,N-dimethylcarbamate
分子量
Average: 367.44
Monoisotopic: 367.210721053
CAS号
81732-46-9
ATC分类
R03C 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Bambuterol is a long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.

生产厂家
    封装厂家
    参考
    Synthesis Reference Not Available
    General Reference Not Available
    剂型
    规格
    化合物类型
    Type small molecule
    Classes
    • Benzyl Alcohols and Derivatives
    • Phenols and Derivatives
    • Phenethylamines
    • Anisoles
    Substructures
    • Hydroxy Compounds
    • Benzyl Alcohols and Derivatives
    • Carbamates and Derivatives
    • Aliphatic and Aryl Amines
    • Phenols and Derivatives
    • Ethers
    • Benzene and Derivatives
    • Amino Alcohols
    • Phenethylamines
    • Aromatic compounds
    • Anisoles
    • Alcohols and Polyols
    • Phenyl Esters
    适应症
    药理
    Indication For the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
    Pharmacodynamics Bambuterol is a long acting beta2-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline. Bambuterol causes smooth muscle relaxation, resulting in dilation of bronchial passages.
    Mechanism of action The pharmacologic effects of bambuterol are at least in part attributable to stimulation through beta-adrenergic receptors (beta 2 receptors) of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic AMP. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
    Absorption Bioavailability is 20% following oral administration.
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Hepatic, extensive. Further metabolized to terbutaline by plasma cholinesterase.

    Important The metabolism module of DrugBank is currently in beta. Questions or suggestions? Please contact us.

    Substrate Enzymes Product
    Bambuterol
    		terbutaline Details
    Route of elimination Not Available
    Half life 13 hours for bambuterol and 21 hours for the primary active metabolite terbutaline.
    Clearance Not Available
    Toxicity Not Available
    Affected organisms
    • Humans and other mammals
    Pathways Not Available
    理化性质
    Properties
    State solid
    Experimental Properties Not Available
    Predicted Properties
    Property Value Source
    water solubility 4.69e-01 g/l ALOGPS
    logP 1.69 ALOGPS
    logP 1.4 ChemAxon
    logS -2.9 ALOGPS
    pKa (strongest acidic) 13.91 ChemAxon
    pKa (strongest basic) 9.52 ChemAxon
    physiological charge 1 ChemAxon
    hydrogen acceptor count 4 ChemAxon
    hydrogen donor count 2 ChemAxon
    polar surface area 91.34 ChemAxon
    rotatable bond count 8 ChemAxon
    refractivity 98.28 ChemAxon
    polarizability 40.74 ChemAxon
    药物相互作用
    Drug Interaction
    Indacaterol Concomitant use with other inhaled, long acting beta2-adrenergic drugs may result in an overdose. Adverse cardiovascular effects and fatalities have been associated with excessive use of inhaled sympathomimetic drugs.
    食物相互作用
    Not Available

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