药品详细
Benzocaine(苯佐卡因)
化学结构式图
中文名
苯佐卡因
英文名
Benzocaine
分子式
C9H11NO2
化学名
ethyl 4-aminobenzoate
分子量
Average: 165.1891
Monoisotopic: 165.078978601
Monoisotopic: 165.078978601
CAS号
94-09-7
ATC分类
C05A 未知;D04A 未知;N01B 未知;R02A 未知;A01A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
A surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. [PubChem]
生产厂家
封装厂家
- Advanced Pharmaceutical Services Inc.
- Aidarex Pharmacuticals LLC
- Alba Pharmacal
- American Dental Cooperative Inc.
- AR Medicom Inc.
- Assured Packaging Inc.
- Ballay Pharmaceuticals
- Bausch & Lomb Inc.
- Belport Co. Inc.
- Benco Dental Co.
- Beutlich Pharmaceuticals LP
- Bio Pharm Inc.
- Boca Pharmacal
- Burkhart Dental Supply Inc.
- Cao Group Inc.
- Combe Inc.
- County Line Pharmaceuticals LLC
- Cross Country Paper Products Corp.
- Crosstex International
- Deepak Products Inc.
- Dental Resources Inc.
- Dental Technologies Inc.
- DENTSPLY International
- Dispensing Solutions
- Diversified Healthcare Services Inc.
- DSHealthcare Inc.
- Essence Dental LLC
- Foremost Dental LLC
- Germiphene Corp.
- Great Southern Laboratories
- Henry Schein Inc.
- Hi Tech Pharmacal Co. Inc.
- Irisys Inc.
- Laboratorios Zeyco SA De CV
- Major Pharmaceuticals
- Mallinckrodt Inc.
- Marlop Pharmaceuticals Inc.
- Medical Products Laboratories Inc.
- Medtech Labs
- Palmetto Pharmaceuticals Inc.
- Patterson Dental Supply Inc.
- Perrigo Co.
- Pharmedix
- Physicians Total Care Inc.
- Preferred Pharmaceuticals Inc.
- Prescript Pharmaceuticals
- PruGen Inc. Pharmaceuticals
- Puretek Corp.
- Qualitest
- Rebel Distributors Corp.
- Redpharm Drug
- River's Edge Pharmaceuticals
- Sciarra Laboratories Inc.
- SDA Laboratories Inc.
- Sonar Products Inc.
- Sunstar Pharmaceutical Inc.
- Taro Pharmaceuticals USA
- Taylor Pharmaceuticals
- Trigen Laboratories Inc.
- UCB Pharma
- Vintage Pharmaceuticals Inc.
- Wyeth Pharmaceuticals
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | For general use as a lubricant and topical anesthetic on esophagus, larynx, mouth, nasal cavity, rectum, respiratory tract or trachea, urinary tract, vagina. It is also used to suppress gag reflex. | ||||||
| Pharmacodynamics | Benzocaine is a local anesthetic commonly used as a topical pain reliever. It is the active ingredient in many over-the-counter analgesic ointments. It is also indicated for general use as a lubricant and topical anesthetic on intratracheal catheters and pharyngeal and nasal airways to obtund the pharyngeal and tracheal reflexes; on nasogastric and endoscopic tubes; urinary catheters; laryngoscopes; proctoscopes; sigmoidoscopes and vaginal specula. | ||||||
| Mechanism of action | Benzocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses. | ||||||
| Absorption | Not Available | ||||||
| Volume of distribution | Not Available | ||||||
| Protein binding | Not Available | ||||||
| Metabolism |
Not Available
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| Route of elimination | Not Available | ||||||
| Half life | Not Available | ||||||
| Clearance | Not Available | ||||||
| Toxicity | LD50=3040 mg/kg (rat, oral) | ||||||
| Affected organisms |
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| Pathways |
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理化性质
| Properties | ||||||||||||||||||||||||||||||||||||||||
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| State | solid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
Not Available
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