用户名： 密   码：
注册 | 忘记密码？
药品详细

Benzyl alcohol(苯甲醇)

化学结构式图
中文名
苯甲醇
英文名
Benzyl alcohol
分子式
C7H8O
化学名
phenylmethanol
分子量
Average: 108.1378
Monoisotopic: 108.057514878
CAS号
100-51-6
ATC分类
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Not Available
生产厂家
    封装厂家
    参考
    Synthesis Reference

    C6H5CH2Cl + NaOH → C6H5CH2OH + NaCl
    General Reference
    1. Taylor PM, Chengelis CP, Miller WR, Parker GA, Gleason TR, Cozzi E: Evaluation of propofol containing 2% benzyl alcohol preservative in cats. J Feline Med Surg. 2012 Aug;14(8):516-26. doi: 10.1177/1098612X12440354. Epub 2012 Feb 24. Pubmed
    2. Novak E, Stubbs SS, Sanborn EC, Eustice RM: The tolerance and safety of intravenously administered benzyl alcohol in methylprednisolone sodium succinate formulations in normal human subjects. Toxicol Appl Pharmacol. 1972 Sep;23(1):54-61. Pubmed
    3. Meinking TL, Villar ME, Vicaria M, Eyerdam DH, Paquet D, Mertz-Rivera K, Rivera HF, Hiriart J, Reyna S: The clinical trials supporting benzyl alcohol lotion 5% (Ulesfia): a safe and effective topical treatment for head lice (pediculosis humanus capitis). Pediatr Dermatol. 2010 Jan-Feb;27(1):19-24. doi: 10.1111/j.1525-1470.2009.01059.×. Pubmed 20199404
    剂型
    规格
    化合物类型
    Type small molecule
    Classes Not Available
    Substructures Not Available
    适应症
    药理
    Indication Ulesfia (benzyl alcohol) Lotion is indicated for the topical treatment of head lice infestation in patients 6 months of age and older. Ulesfia Lotion does not have ovicidal activity.
    Pharmacodynamics Not Available
    Mechanism of action Benzyl alcohol inhibits lice from closing their respiratory spiracles, allowing the vehicle to obstruct the spiracles and causing the lice to asphyxiate.
    Absorption Not Available
    Volume of distribution Not Available
    Protein binding Not Available
    Metabolism
    Not Available
    Route of elimination Not Available
    Half life Not Available
    Clearance Not Available
    Toxicity 1250 mg/kg (rat, oral) LD50 400 mg/kg IPR-RAT LD50 2000 mg/kg SKN-RBT LD50 53 mg/kg IVN-RAT LD50 2500 mg/kg ORL-GPG LD50
    Affected organisms
    • Head lice
    Pathways Not Available
    理化性质
    Properties
    State liquid
    Experimental Properties
    Property Value Source
    melting point -15..2 °C, 258 K, 5 °F # http://sitem.herts.ac.uk/aeru/footprint/en/Reports/953.htm.
    boiling point 205.3 °C, 478 K, 402 °F # http://sitem.herts.ac.uk/aeru/footprint/en/Reports/953.htm.
    water solubility 33 mg/mL, clear, colorless # http://www.chemicalbook.com/ProductChemicalPropertiesCB3852587_EN.htm
    logP 1.1 # http://sitem.herts.ac.uk/aeru/footprint/en/Reports/953.htm.
    pKa 15.4 # http://sitem.herts.ac.uk/aeru/footprint/en/Reports/953.htm.
    Predicted Properties
    Property Value Source
    water solubility 2.68e+01 g/l ALOGPS
    logP 1.07 ALOGPS
    logP 1.21 ChemAxon
    logS -0.61 ALOGPS
    pKa (strongest acidic) 15.02 ChemAxon
    pKa (strongest basic) -2.8 ChemAxon
    physiological charge 0 ChemAxon
    hydrogen acceptor count 1 ChemAxon
    hydrogen donor count 1 ChemAxon
    polar surface area 20.23 ChemAxon
    rotatable bond count 1 ChemAxon
    refractivity 32.87 ChemAxon
    polarizability 11.89 ChemAxon
    药物相互作用
    食物相互作用
    Not Available

    返回 | 收藏