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药品详细

Benzyl Benzoate(苯甲酸苄酯)

化学结构式图
中文名
苯甲酸苄酯
英文名
Benzyl Benzoate
分子式
C14H12O2
化学名
benzyl benzoate
分子量
Average: 212.2439
Monoisotopic: 212.083729628
CAS号
120-51-4
ATC分类
P03A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.

生产厂家
  • Lannett co inc
封装厂家
参考
Synthesis Reference Not Available
General Reference
  1. Bachewar NP, Thawani VR, Mali SN, Gharpure KJ, Shingade VP, Dakhale GN: Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies. Indian J Pharmacol. 2009 Feb;41(1):9-14. Pubmed
  2. Buffet M, Dupin N: Current treatments for scabies. Fundam Clin Pharmacol. 2003 Apr;17(2):217-25. Pubmed
剂型
规格
化合物类型
Type small molecule
Classes
  • Aminobenzoates
  • Benzene and Derivatives
  • Benzyl Esters
  • Benzylacetates
Substructures
  • Aminobenzoates
  • Carboxylic Acids and Derivatives
  • Benzyl Alcohols and Derivatives
  • Acetates
  • Benzoates
  • Ethers
  • Benzene and Derivatives
  • Benzyl Esters
  • Benzylacetates
  • Aromatic compounds
  • Benzoyl Derivatives
适应症
药理
Indication Used to kill lice and the mites responsible for the skin condition scabies.
Pharmacodynamics Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.
Mechanism of action Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes.
Absorption No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified.
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Oral, rabbit: LD50 = 1680 mg/kg; Skin, rabbit: LD50 = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.
Affected organisms
  • Sarcoptes scabiei
Pathways Not Available
理化性质
Properties
State liquid
Experimental Properties
Property Value Source
melting point 21 °C PhysProp
boiling point 323.5 °C PhysProp
water solubility 15.4 mg/L Not Available
logP 3.97 HANSCH,C ET AL. (1995)
Predicted Properties
Property Value Source
water solubility 1.98e-02 g/l ALOGPS
logP 3.43 ALOGPS
logP 3.7 ChemAxon
logS -4 ALOGPS
pKa (strongest basic) -6.9 ChemAxon
physiological charge 0 ChemAxon
hydrogen acceptor count 1 ChemAxon
hydrogen donor count 0 ChemAxon
polar surface area 26.3 ChemAxon
rotatable bond count 4 ChemAxon
refractivity 62.7 ChemAxon
polarizability 22.85 ChemAxon
药物相互作用
食物相互作用
Not Available

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