药品详细
Betazole(培他唑)
化学结构式图
中文名
培他唑
英文名
Betazole
分子式
C5H9N3
化学名
2-(1H-pyrazol-5-yl)ethan-1-amine
分子量
Average: 111.1451
Monoisotopic: 111.079647303
Monoisotopic: 111.079647303
CAS号
105-20-4
ATC分类
V04C 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
A histamine H2 agonist used clinically to test gastric secretory function. [PubChem]
生产厂家
- Eli lilly and co
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | For use clinically to test gastric secretory function. |
| Pharmacodynamics | Betazole is a histamine H2 agonist used in a test for measuring maximal production of gastric acidity or anacidity. This measurement can be used to diagnose diseases such as Zollinger-Ellison syndrome, whereby the volume of gastric and basal secretions is measured following betazole administration (greater than 60% of the maximal acid secretion following betazole stimulation). In another test, gastritis can be diagnosed given late absence of gastric acid which is unresponsive to betazole stimulation. Betazole can be used as a gastric secretory stimulant instead of histamine with the advantage of not provoking side effects and thus not requiring the use of antihistaminic compounds. |
| Mechanism of action | Betazole is a histamine analogue. It produces the same effects as histamine, binding the H2 receptor which is a mediator of gastric acid secretion. This agonist action thereby results in an increase in the volume of gastric acid produced. |
| Absorption | Rapid and complete. |
| Volume of distribution | Not Available |
| Protein binding | > 99% |
| Metabolism |
Not Available
|
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Not Available |
| Affected organisms |
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| Pathways | Not Available |
理化性质
| Properties | |||||||||||||||||||||||||||||||||||||||||||
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| State | liquid | ||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
Not Available
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