药品详细
Bethanechol(胆碱)
化学结构式图
中文名
胆碱
英文名
Bethanechol
分子式
C7H17N2O2
化学名
1-(trimethylazaniumyl)propan-2-yl carbamate
分子量
Average: 161.2221
Monoisotopic: 161.129002798
Monoisotopic: 161.129002798
CAS号
674-38-4
ATC分类
N07A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Bethanechol is a synthetic ester structurally and pharmacologically related to acetylcholine. A slowly hydrolyzed muscarinic agonist with no nicotinic effects, bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, cardiac rate changes, and bronchial spasms. [PubChem]
生产厂家
- Able laboratories inc
- Actavis totowa llc
- Amneal pharmaceutical
- Ascot hosp pharmaceuticals inc div travenol laboratories inc
- Emcure pharmaceuticals usa inc
- Glenwood inc
- Impax laboratories inc
- Ivax pharmaceuticals inc sub teva pharmaceuticals usa
- Lannett co inc
- Lannett holdings inc
- Odyssey pharmaceuticals inc
- Pharmax group inc
- Sandoz inc
- Sun pharmaceutical industries inc
- Upsher smith laboratories inc
- Watson laboratories inc
- Wellspring pharmaceutical corp
- Wockhardt ltd
封装厂家
- Actavis Group
- Amerisource Health Services Corp.
- Amneal Pharmaceuticals
- Ascend Laboratories LLC
- Caraco Pharmaceutical Labs
- Duramed
- Global Pharmaceuticals
- Heartland Repack Services LLC
- Impax Laboratories Inc.
- Lannett Co. Inc.
- Major Pharmaceuticals
- Medisca Inc.
- Murfreesboro Pharmaceutical Nursing Supply
- PD-Rx Pharmaceuticals Inc.
- Pharmaceutical Utilization Management Program VA Inc.
- Pharmacy Service Center
- Physicians Total Care Inc.
- Pliva Inc.
- QPharm Inc.
- Ranbaxy Laboratories
- Resource Optimization and Innovation LLC
- Sandhills Packaging Inc.
- Southwood Pharmaceuticals
- Sun Pharmaceutical Industries Ltd.
- United Research Laboratories Inc.
- USL Pharma Inc.
- Vangard Labs Inc.
- Wellspring Pharmaceutical
- Wockhardt Ltd.
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | For the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention. |
| Pharmacodynamics | Bethanechol is a parasympathomimetic (cholinergic) used for the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention. Bethanechol, a cholinergic agent, is a synthetic ester which is structurally and pharmacologically related to acetylcholine. It increases the tone of the detrusor urinae muscle, usually producing a contraction sufficiently strong to initiate micturition and empty the bladder. It stimulates gastric motility, increases gastric tone, and often restores impaired rhythmic peristalsis. Bethanechol chloride is not destroyed by cholinesterase and its effects are more prolonged than those of acetytcholine. |
| Mechanism of action | Bethanechol directly stimulates cholinergic receptors in the parasympathetic nervous system while stimulating the ganglia to a lesser extent. Its effects are predominantly muscarinic, inducing little effect on nicotinic receptors and negligible effects on the cardiovascular system. |
| Absorption | Not Available |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Not Available
|
| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Pathways | Not Available |
理化性质
| Properties | ||||||||||||||||||||||||||||||||||||||||
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| State | solid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
| Drug | Interaction |
|---|---|
| Tacrine | The acetylcholinesterase inhibitor, Tacrine, may increase the cholinergic effects of Bethanecol, a cholinergic agonist. Monitor for increased cholinergic effects. |
食物相互作用
- Take on empty stomach: 1 hour before or 2 hours after meals to avoid nausea.
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