药品详细

Bethanidine(苄二甲胍)

基本信息
剂型规格
适应症
药理
临床
理化性质
相互作用
文档
专利
Pathway
文献
序列

化学结构式图

中文名

苄二甲胍

英文名

Bethanidine

分子式

C₁₀H₁₅N₃

化学名

(E)-3-benzyl-1,2-dimethylguanidine

分子量

Average: 177.2462
Monoisotopic: 177.126597495

CAS号

55-73-2

ATC分类

C02C 未知

药物类型

small molecule

阶段

approved

商品名

同义名

基本介绍

A guanidinium antihypertensive agent that acts by blocking adrenergic transmission.

生产厂家

Ah robins co

封装厂家

参考

Synthesis Reference	Not Available
General Reference	Not Available

剂型

规格

化合物类型

Type	small molecule

Classes

Not Available

Substructures

Not Available

适应症

药理

Indication	For the treatment of hypertension.
Pharmacodynamics	Bethanidine is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear. Although bethanidine may produce adverse effects, they are beneficial in severe hypertension and produce fewer side effects than guanethidine.
Mechanism of action	Bethanidine, a guanidine derivative, is a peripherally acting antiadrenergic agent which primarily acts as an alpha2a adrenergic agonist. Bethanidine effectively decreases blood pressure by suppressing renin secretion or interfering with function of the sympathetic nervous system.
Absorption	Absorbed rapidly in the gastrointestinal tract following oral administration.
Volume of distribution	Not Available
Protein binding	Not Available
Metabolism	Not Available
Route of elimination	Not Available
Half life	9 hours (range 7 to 11 hours)
Clearance	Not Available
Toxicity	Not Available
Affected organisms	Humans and other mammals
Pathways	Not Available

理化性质

Properties

State

solid

Experimental Properties

Property	Value	Source
melting point	196 °C	PhysProp
logP	0.49	Not Available

Predicted Properties

Property	Value	Source
water solubility	1.58e+00 g/l	ALOGPS
logP	1.41	ALOGPS
logP	1.27	ChemAxon
logS	-2	ALOGPS
pKa (strongest basic)	12.41	ChemAxon
physiological charge	1	ChemAxon
hydrogen acceptor count	3	ChemAxon
hydrogen donor count	2	ChemAxon
polar surface area	36.42	ChemAxon
rotatable bond count	2	ChemAxon
refractivity	54.5	ChemAxon
polarizability	20.43	ChemAxon

药物相互作用

食物相互作用

Not Available

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