药品详细
Butoconazole(布康唑)
化学结构式图
中文名
布康唑
英文名
Butoconazole
分子式
C19H17Cl3N2S
化学名
1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl]-1H-imidazole
分子量
Average: 411.776
Monoisotopic: 410.017802365
Monoisotopic: 410.017802365
CAS号
64872-77-1
ATC分类
G01A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍
Butoconazole is an imidazole antifungal used in gynecology.
生产厂家
- Bayer healthcare llc
- Kv pharmaceutical co
- Roche palo alto llc
封装厂家
参考
| Synthesis Reference | Not Available |
| General Reference | Not Available |
剂型
规格
化合物类型
| Type | small molecule |
| Classes |
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| Substructures |
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适应症
药理
| Indication | For the local treatment of vulvovaginal candidiasis (infections caused by Candida) |
| Pharmacodynamics | Butoconazole is an imidazole derivative that has fungicidal activity in vitro against Candida spp. and has been demonstrated to be clinically effective against vaginal infections due to Candida albicans. Candida albicans has been identified as the predominant species responsible for vulvovaginal candidasis. |
| Mechanism of action | The exact mechanism of the antifungal action of butoconazole is unknown, however, it is presumed to function as other imidazole derivatives via inhibition of steroid synthesis. Imidazoles generally inhibit the conversion of lanosterol to ergosterol via the inhibition of the enzyme cytochrome P450 14α-demethylase, resulting in a change in fungal cell membrane lipid composition. This structural change alters cell permeability and, ultimately, results in the osmotic disruption or growth inhibition of the fungal cell. |
| Absorption | Following vaginal administration of butoconazole nitrate vaginal cream, 2% to 3 women, 1.7% (range 1.3-2.2%) of the dose was absorbed on average. |
| Volume of distribution | Not Available |
| Protein binding | Not Available |
| Metabolism |
Not Available
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| Route of elimination | Not Available |
| Half life | Not Available |
| Clearance | Not Available |
| Toxicity | Oral, rat: LD50 = >1720 mg/kg. |
| Affected organisms |
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| Pathways | Not Available |
理化性质
| Properties | ||||||||||||||||||||||||||||||||||||||||
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| State | solid | |||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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药物相互作用
食物相互作用
Not Available
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