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药品详细

Calcium Gluceptate(葡庚糖酸钙)

化学结构式图
中文名
葡庚糖酸钙
英文名
Calcium Gluceptate
分子式
C14H26CaO16
化学名
calcium bis((3R,4S,5R,6R)-2,3,4,5,6,7-hexahydroxyheptanoate)
分子量
Average: 490.425
Monoisotopic: 490.084675939
CAS号
29039-00-7
ATC分类
A12A 未知
药物类型
small molecule
阶段
approved
商品名
同义名
基本介绍

Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium. They are used to prevent or treat several conditions that may cause hypocalcemia (not enough calcium in the blood). The body needs calcium to make strong bones. Calcium is also needed for the heart, muscles, and nervous system to work properly.

生产厂家
  • Abbott laboratories pharmaceutical products div
  • Abraxis pharmaceutical products
  • Eli lilly and co
封装厂家
参考
Synthesis Reference Not Available
General Reference
  1. Drop LJ, Cullen DJ: Comparative effects of calcium chloride and calcium gluceptate. Br J Anaesth. 1980 May;52(5):501-5. Pubmed
剂型
规格
化合物类型
Type small molecule
Classes
  • Carbohydrates
Substructures
  • Glycerol and Derivatives
  • Hydroxy Compounds
  • Anions
  • Acetates
  • Short-chain Hydroxy Acids
  • Carboxylic Acids and Derivatives
  • Alcohols and Polyols
  • Carbohydrates
  • Cations
适应症
药理
Indication For treatment of mild hypocalcemia due to neonatal tetany, tetany due to parathyroid deficiency or vitamin D deficiency, and alkalosis, as prophylaxis of hypocalcemia during exchange transfusions, in the treatment of intestinal malabsorption, and to replenish electrolytes.
Pharmacodynamics Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium. They are used to prevent or treat several conditions that may cause hypocalcemia (not enough calcium in the blood). The body needs calcium to make strong bones. Calcium is also needed for the heart, muscles, and nervous system to work properly. The bones serve as a storage site for the body's calcium. They are continuously giving up calcium to the bloodstream and then replacing it as the body's need for calcium changes from day to day. When there is not enough calcium in the blood to be used by the heart and other organs, your body will take the needed calcium from the bones. When you eat foods rich in calcium, the calcium will be restored to the bones and the balance between your blood and bones will be maintained.
Mechanism of action Calcium gluceptate replenishes the deminished levels of calcium in the body, returning them to normal levels.
Absorption Rapidly absorbed following oral administration.
Volume of distribution Not Available
Protein binding Not Available
Metabolism
Not Available
Route of elimination Not Available
Half life Not Available
Clearance Not Available
Toxicity Symptoms of overdose include confusion, drowsiness (severe), high blood pressure, increased sensitivity of eyes or skin to light, irregular, fast, or slow heartbeat, and unusually large amount of urine or increased frequency of urination.
Affected organisms
  • Humans and other mammals
Pathways Not Available
理化性质
Properties
State solid
Experimental Properties
Property Value Source
water solubility Soluble Not Available
Predicted Properties
Property Value Source
water solubility 3.98e+01 g/l ALOGPS
logP -1.9 ALOGPS
logP -4 ChemAxon
logS -1.1 ALOGPS
pKa (strongest acidic) 3.38 ChemAxon
pKa (strongest basic) -3 ChemAxon
physiological charge -1 ChemAxon
hydrogen acceptor count 8 ChemAxon
hydrogen donor count 6 ChemAxon
polar surface area 161.51 ChemAxon
rotatable bond count 12 ChemAxon
refractivity 55.07 ChemAxon
polarizability 19.35 ChemAxon
药物相互作用
Drug Interaction
Trovafloxacin Calcium may decrease the absorption of orally administered Trovafloxacin. Administer Trovafloxacin 2 hours before or 6 hours after a dose of the calcium containing agent to minimize the interaction.
食物相互作用
Not Available

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